THYMOQUINONE AND BLACK SEED COMPOSITIONS FOR TREATING NEUROENDOCRINE CANCER IN COMBINATION WITH IMMUNOTHERAPY

Abstract: composition and methods for immunotherapy of a cancer patient, comprising administering a black seed oil composition or one or more components thereof, which can include thymoquinone, oleic acid, linoleic acid, palmitic acid, eicosapentaenoic acid, or docosahexaenoic acid. the composition or components can be administered in combination with one or more immune checkpoint inhibitors, including anti-cla-4 agents and anti-pd-1 agents. the cancers targeted by the compositions and combinations include neuroendocrine cancers, and, in particular, high grade neoplasms and poorly differentiated neuroendocrine carcinomas, including advanced or metastatic neuroendocrine carcinomas and, more particularly, refractory advanced or metastatic gastroenteropancreatic neuroendocrine carcinomas.

Inventor(s): Abdulhafez Selim, Ahmed Omar Kaseb, Mohamed Kaseb, Amr Mohamed

CPC Classification: A61K31/122 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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