MULTILAYER POROUS MEMBRANE

Abstract: the invention relates to a therapeutic composition comprising an inner portion and a biocompatible membrane fully or partially surrounding the inner portion. the biocompatible membrane comprises at least two layers: a first layer of a porous, nonwoven network of thermoplastic polyurethane polymer fibers formed by electrospinning and having a porosity of greater than or equal to 50%; an average pore diameter of less than 5 �m; and has a thickness in the range of 10 �m to 250 �m; and a second layer of a porous, nonwoven network of thermoplastic polymer fibers formed by electrospinning. the second layer has a mean average fiber diameter of the second layer is greater than the mean average fiber diameter in the first layer, and/or wherein the average pore diameter of the second layer is greater than the average pore diameter of the first layer. the inner portion comprises a therapeutic agent. the invention also relates to uses of the membrane and therapeutic composition, for instance, to encapsulate therapeutic cells.

Inventor(s): Robert James McKean, Teodor-Matei Cirstea, Brendan John Robb

CPC Classification: A61K9/70 (Web, sheet or filament bases {; Films; Fibres of the matrix type containing drug (hollow drug-filled fibres )})

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