Anti-cMET Antibodies and Methods of Use

Abstract: the present disclosure provides for antibody or antigen-binding fragment thereof that specifically binds to human cmet and multispecific antibody or antigen-binding fragment thereof, comprising a first antigen binding domain that specifically binds a first epitope of human cmet; a second antigen binding domain that specifically binds to a second epitope of human cmet; and a third antigen binding domain that specifically binds to human egfr; wherein the first epitope is distinct from the second epitope, or wherein the first antigen binding domain does not compete with the second antigen binding domain. the present disclosure also provides for the use of the antibodies or multispecific antibodies for treating a disease, such as cancer.

Inventor(s): Renke Li, Xiaoyan Tang, Mengran Qian, Jie Pan, Zhao Zhao, Xi Wu, Ming Jiang, Hui Li, Xiaona Sun, Yanzhou Zhang, Mengmeng Lu, Yun Chen

CPC Classification: C07K16/2863 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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