ANTI-ALK1 ANTIBODIES AND METHODS OF USING THE SAME

Abstract: the present disclosure provides antibodies that bind to alk1 and methods/uses of the disclosed antibodies for treating various conditions (e.g., atherosclerosis). the present disclosure provides anti-alk1 antibodies, comprising the complementarity determining regions (cdrs) of a heavy chain variable sequence and a light chain variable sequence selected from: the heavy chain variable sequence of seq id no: 2 and the light chain variable sequence of seq id no: 3. in some embodiments, the disclosed antibodies bind to human alk1, murine alk1, cynomolgus alk1, or a combination thereof. the present disclosure also provides pharmaceutical compositions comprising an anti-alk1 antibody accordingly to any one of the foregoing aspects or embodiments and a pharmaceutically acceptable carrier.

Inventor(s): Hubertus Schleer, William Sessa

CPC Classification: C07K16/2863 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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