ANTIBODIES TO PROGRAMMED CELL DEATH PROTEIN 1

Abstract: antibodies and antigen binding fragments thereof are provided that immunospecifically bind to pd-1 and induce or promote an immune response that activates immune cell proliferation or activity. contrary to the existing paradigm that pd-1 exclusively promotes a suppressive immune response, the disclosed antibodies and antigen binding fragments thereof, immunospecifically bind to pd-1 and cause an activating signal to be delivered to the immune cell that activates the immune cell rather than suppressing the immune cell. in one embodiment, the disclosed antibodies and antigen binding fragments thereof specifically bind to pd-1 expressed on immune cells. the binding of the disclosed antibodies and antigen binding fragments thereof to pd-1 on immune cells causes an activating signal to be transmitted into the immune cell, for example a signal that enhances or promotes cytokine production and/or activation of immune cell proliferation.

Inventor(s): Samir Khleif, Mikayel Mkrtichyan

CPC Classification: C07K16/2818 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

Search for rejections for patent application number 20250154256