HUMAN ANTIBODIES THAT BIND LYMPHOCYTE ACTIVATION GENE-3 (LAG-3), AND USES THEREOF

Abstract: the present disclosure provides isolated monoclonal antibodies that specifically bind to lag-3 with high affinity, particularly human monoclonal antibodies. preferably, the antibodies bind human lag-3. in certain embodiments, the antibodies bind both human and monkey lag-3 but do not bind mouse lag-3. the invention provides anti-lag-3 antibodies that can inhibit the binding of lag-3 to mhc class ii molecules and that can stimulate antigen-specific t cell responses. nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. this disclosure also provides methods for detecting lag-3, as well as methods for treating stimulating immune responses using an anti-lag-3 antibody of the invention. combination therapy, in which an anti-lag-3 antibody is co-administered with at least one additional immunostimulatory antibody, is also provided.

Inventor(s): Kent B. THUDIUM, Mark J. SELBY, Kyra D. ZENS, Mark YAMANAKA, Alan J. KORMAN, Heidi N. LEBLANC

CPC Classification: C07K16/2803 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

Search for rejections for patent application number 20250154254