D-DOMAIN CONTAINING POLYPEPTIDES AND USES THEREOF

Abstract: d domain (dd) containing polypeptides (ddpp) that specifically bind targets of interest (e.g., bcma, cd123, cs1, her2, afp, and afp p26) are provided, as are nucleic acids encoding the ddpp, vectors containing the nucleic acids and host cells containing the nucleic acids and vectors. ddpp such as ddpp fusion proteins, are also provided as are methods of making and using the ddpp. such uses include, but are not limited to diagnostic and therapeutic applications.

Inventor(s): David M. HILBERT, Jeffrey S. SWERS

CPC Classification: C07K14/7051 (PEPTIDES (peptides in foodstuffs ; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs ; preparations for medicinal purposes ; peptides containing beta-lactam rings ; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, ; ergot alkaloids of the cyclic peptide type ; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids ; macromolecular products derived from proteins ; preparation of glue or gelatine ; single cell proteins, enzymes ; genetic engineering processes for obtaining peptides ; compositions for measuring or testing processes involving enzymes ; investigation or analysis of biological material ))

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