NERVE GRAFTS AND METHODS OF PREPARATION THEREOF

Abstract: tissue grafts with reduced regenerative potential, methods of preparing such grafts, and related kits and methods of treatment are described. the method may include treating tissue with a digestion solution comprising trypsin, alpha-chymotrypsin (act) and optionally ethylenediaminetetraacetic acid (edta) to substantially remove one or more susceptible proteins from the tissue. the method may also include washing the treated tissue with a buffer solution and/or with a serine-containing serum. nerve grafts prepared according to the disclosed methods may inhibit, or lessen (e.g., provide for reduced) neuroma formation and/or axonal outgrowth after implantation.

Inventor(s): Jennifer FALERIS, Kasra TAJDARAN

CPC Classification: A61L27/3675 (METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed ; preserving, e.g. sterilising, food or foodstuffs ; preparations for medical, dental or toiletry purposes ))

Search for rejections for patent application number 20250152779