Radiopharmaceutical Compositions of Radioactive Halogenated Benzylguandine

Abstract: the present disclosure concerns radiopharmaceutical compositions of radioactive halogenated benzylguanidine (such as radioiodinated mibg) or a pharmaceutically acceptable salt, hydrate, or solvate thereof. in a preferred embodiment, the composition has at least 97% of radiochemical purity for at least 4 days. advantageously, the compositions of the present disclosure may be devoid of parabens, which are carcinogenic and yet are used in known radioactive mibg compositions. the present disclosure also provides processes of preparing a radioactive halogenated benzylguanidine composition. the compositions of the present disclosure can be used in diagnosis and treatment of various diseases.

Inventor(s): Robert William Riddoch, Abmel Xiques Castillo

CPC Classification: A61K51/04 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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