FORMULATION OF CONTRAST MEDIA AND PROCESS OF PREPARATION THEREOF

Abstract: the present disclosure relates to a liquid pharmaceutical formulation comprising a do3a-derived tetra-chelate of formula (i), in which m is an ion of a paramagnetic metal, preferably a gd ion, and r, r, r, rand rare as defined in the claims, in a pharmaceutical acceptable solvent. the present disclosure also relates to a method of preparation of said liquid pharmaceutical formulation and to a method of imaging involving said liquid pharmaceutical formulation.

Inventor(s): Stephan Holzschuh, Thomas Frenzel, Gregor Jost, Jessica Lohrke, Wolfgang Ebert, Thomas Brumby, Wolfgang Halfbrodt

CPC Classification: A61K49/108 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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