IMMUNE SYSTEM MODULATORS AND USES THEREOF

Abstract: the disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. compositions described herein include lipid carriers, optionally including an inorganic particle, capable of admixing with nucleic acids. compositions optionally comprising a nanoparticle carrier and nucleic acid sequence(s) encoding for (i) a cytokine; and (ii) an innate immune stimulator are provided. further provided are compositions optionally comprising a nanoparticle carrier; an innate immune stimulator; and a nucleic acid sequence encoding for a cytokine. methods of using the compositions as a therapeutic vaccine for the treatment of a cancer are also provided.

Inventor(s): Lars Peter Aksel BERGLUND, Steven James REED

CPC Classification: A61K48/0033 (Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy)

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