METHODS AND COMPOSITIONS FOR VACCINATION AGAINST HETEROSUBTYPIC INFLUENZA VIRUSES USING AN ADENOVIRAL VECTOR LEADING TO ENHANCED T CELL RESPONSE THROUGH AUTOPHAGY

Abstract: an adenoviral vector with e1 and e3 regions removed and expressing the nucleoprotein or other immunogenic domain(s) of an influenza virus with or without the presence of the autophagy-inducing peptide c5 (aip-c5) from the cfp10 protein of , compositions comprising same, and methods of use for general vaccination against heterosubtypic influenza viruses.

Inventor(s): Suresh MITTAL, Suryaprakash SAMBHARA, Ekramy SAYEDAHMED, Chinnaswamy JAGANNATH

CPC Classification: A61K39/145 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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