METHOD OF MAKING A PERSONALIZED CANCER VACCINE

Abstract: a method of making a personalized cancer vaccine is disclosed. the method includes predicting whether a first neoantigen or a second neoantigen of an individual cancer patient has a stronger binding affinity for a human leukocyte antigen (hla) complex of the patient and creating a particle containing the neoantigen with the stronger predicted binding affinity. the predicting step can be implemented using artificial intelligence, statistical modeling, or a combination thereof. particles are created by encapsulating the neoantigen with the stronger predicted binding affinity for the hla complex of the patient in a biocompatible material. placing the antigen in a particular sized particle is referred to here as size exclusion antigen presentation control, (seapac) used in methods of treating the patient using such a personalized cancer vaccine.

Inventor(s): REID M. RUBSAMEN, CHARLES V. HERST, LU WANG, SCOTT R. BURKHOLZ, RICHARD T. CARBACK, III, SERBAN I. CIOTIOS

CPC Classification: A61K39/0011 (Medicinal preparations containing antigens or antibodies (materials for immunoassay ))

Search for rejections for patent application number 20250152685