COMPOSITIONS COMPRISING GLUCOCEREBROCIDASE AND METHODS OF USE THEREOF

Abstract: provided are compositions comprising glucocerebrosidase having increased phosphorylation of high mannose and hybrid n-linked oligosaccharides. also provided herein are methods of treating gaucher disease comprising administering to a subject the compositions of the disclosure.

Inventor(s): Robert Russell GOTSCHALL, Lin LIU

CPC Classification: A61K38/47 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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