CONSTRUCTION AND APPLICATION OF ENHANCED NEUTROPHIL DRUG

Abstract: the present disclosure relates to construction and an application of an enhanced neutrophil drug, specifically to a construction method for obtaining an enhanced neutrophil, including: performing induction culture of a neutrophil in a medium including any one or more of component a, component b and component c, where the component a includes one or more of ifn�, gm-csf, g-csf, ifn-�, ifn-�, tnf�, lps, il1�, il6, mcp-1, il-23, bcg, or �-glucan; the component b includes one or more of durvalumab, avelumab, atezolizumab, ipilimumab, or tremelimumab; and the component c includes one or more of q-vd-oph, dfo, hsp70, nac, or nec-1. the construction method provided by the present disclosure prolongs the in vitro lifespan of the neutrophil, and enhances tumor-killing activity, an immune activation ability and/or an anti-infection ability.

Inventor(s): Can Zhang, Caoyun Ju, Yijun Chen, Qifan Hu

CPC Classification: A61K35/15 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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