METHODS OF PROVIDING SOLRIAMFETOL THERAPY TO SUBJECTS WITH IMPAIRED RENAL FUNCTION

Abstract: the invention relates to methods for decreasing adverse effects associated with solriamfetol ([r]-2-amino-3-phenylpropylcarbamate) therapy in subjects with impaired renal function. in particular, the invention provides an optimized dose escalation scheme for subjects with moderate renal impairment which results in the subjects having increased tolerance to adverse effects associated with the administration of solriamfetol. the invention also provides adjusted dosing for safe therapeutic use of solriamfetol in subjects having severe renal impairment.

Inventor(s): Katayoun Zomorodi, Herriot Tabuteau

CPC Classification: A61K31/325 (PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms ; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles ; soap compositions ))

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