ENGINEERED PNMA PROTEINS AND DELIVERY SYSTEMS THEREOF

Organization Name

Massachusetts Institute of Technology

Inventor(s)

Feng Zhang of Cambridge MA (US)

Victoria Madigan of Cambridge MA (US)

Yugang Zhang of Cambridge MA (US)

Rumya Raghavan of Cambridge MA (US)

Max Wilkinson of Cambridge MA (US)

Guilhem Faure of Cambridge MA (US)

Rhiannon Macrae of Cambridge MA (US)

ENGINEERED PNMA PROTEINS AND DELIVERY SYSTEMS THEREOF

This abstract first appeared for US patent application 18948601 titled 'ENGINEERED PNMA PROTEINS AND DELIVERY SYSTEMS THEREOF

Original Abstract Submitted

Described herein are engineered paraneoplastic Ma protein (PNMA) capable of forming a capsid. In some embodiments, the engineered PNMA proteins comprise one or more modifications that enhance binding or loading of a cargo into the capsid, one or more modifications that modify cell-specificity of the capsid, one or more modifications that enhance intracellular delivery of the capsid, or a combination thereof. Also described herein are delivery systems comprising capsids comprising an engineered PNMA protein and a cargo.