18932763. PROGRAMMABLE NUCLEASE-PEPTIDASE COMPOSITIONS (Massachusetts Institute of Technology)
PROGRAMMABLE NUCLEASE-PEPTIDASE COMPOSITIONS
Organization Name
Massachusetts Institute of Technology
Inventor(s)
Jonathan Strecker of Cambridge MA US
PROGRAMMABLE NUCLEASE-PEPTIDASE COMPOSITIONS
This abstract first appeared for US patent application 18932763 titled 'PROGRAMMABLE NUCLEASE-PEPTIDASE COMPOSITIONS
Original Abstract Submitted
Described in certain example embodiments herein are programmable nuclease-peptidase compositions, systems, and methods for the manipulation of nucleic acids and/or polypeptides. In some embodiments, the programmable nuclease-peptidase composition comprises a repeat-associated mysterious protein (RAMP) polypeptide; a guide molecule capable of forming a RAMP-guide molecule complex with the RAMP polypeptide and directing sequence specific binding of the complex to a target polynucleotide; and a peptidase capable of binding to the RAMP polypeptide, the guide molecule, or further complexing with the RAMP-guide molecule complex, wherein binding of the RAMP-guide molecule complex to the target polynucleotide initiates binding and/or interaction of the peptidase with a target polypeptide.