18914687. PERTUZUMAB VARIANTS AND EVALUATION THEREOF (Genentech, Inc.)
PERTUZUMAB VARIANTS AND EVALUATION THEREOF
Organization Name
Inventor(s)
Lynn A. Gennaro of San Mateo CA (US)
Yung-Hsiang Kao of San Mateo CA (US)
Yonghua Zhang of Foster City CA (US)
PERTUZUMAB VARIANTS AND EVALUATION THEREOF
This abstract first appeared for US patent application 18914687 titled 'PERTUZUMAB VARIANTS AND EVALUATION THEREOF
Original Abstract Submitted
The present application discloses variants of Pertuzumab. In particular, it discloses: an unpaired cysteine variant comprising Cys23/Cys88 unpaired cysteines in one or both variable light domains of Pertuzumab, an afucosylated variant of Pertuzumab, a low-molecular-weight-species (LMWS) of Pertuzumab, and a high-molecular-weight-species (HMWS) or Pertuzumab. The application further discloses the isolated variants, compositions, pharmaceutical compositions, and articles of manufacture comprising the variants, as well as methods of making and characterizing the variants and compositions thereof.
