18832887. SYNTHESIS OF A KIF18A INHIBITOR (AMGEN INC.)
SYNTHESIS OF A KIF18A INHIBITOR
Organization Name
Inventor(s)
Sebastien Caille of Thousand Oaks CA US
Daniel Gerard Greene of Thousand Oaks CA US
Michael Thomas Corbett of Thousand Oaks CA US
Carolyn Wei of Thousand Oaks CA US
SYNTHESIS OF A KIF18A INHIBITOR
This abstract first appeared for US patent application 18832887 titled 'SYNTHESIS OF A KIF18A INHIBITOR
Original Abstract Submitted
The present invention relates to improved preparation of a KIF18A inhibitor having the chemical structure Compound (1), or a salt thereof Compound (la); wherein HA is as defined herein; and key intermediates thereof, i.e., Compound (2a), Compound (3a), Compound (5) or a salt thereof, and Compound (6a) or a hydrate thereof, of the formulae: Compound (2a); Compound (3a); Compound (5) or a salt thereof; and Compound (6a) or a hydrate thereof, preferably Compound (6a-1). The present invention further relates to solid form of Compound (6a), preferably the crystalline hydrate form of Compound (6a-1).