18821462. POLYANION COATED LIPID NANOPARTICLES AND METHODS OF USE THEREOF (MASSACHUSETTS INSTITUTE OF TECHNOLOGY)

POLYANION COATED LIPID NANOPARTICLES AND METHODS OF USE THEREOF

Organization Name

MASSACHUSETTS INSTITUTE OF TECHNOLOGY

Inventor(s)

Paula T. Hammond-cunningham of Newton MA (US)

Namita Rajesh Nabar of Cambridge MA (US)

Tamara Gomez Dacoba of Somerville MA (US)

POLYANION COATED LIPID NANOPARTICLES AND METHODS OF USE THEREOF

This abstract first appeared for US patent application 18821462 titled 'POLYANION COATED LIPID NANOPARTICLES AND METHODS OF USE THEREOF

Original Abstract Submitted

Described herein are nanoparticles comprising an LNP core with electrostatically adsorbed anionic polymers layered on the LNP surface. These nanoparticles comprise varying nucleic acid cargos and may further comprise targeting moieties covalently attached to the anionic polymers. Also provided are methods of administering cargo to a subject, methods of treatment, methods of editing a gene, and methods of reducing non-targeted cell uptake of nanoparticles.