Fused Pentacyclic Imidazole Derivatives as Modulators of TNF Activity

Organization Name

Sanofi

Inventor(s)

Daniel Christopher Brookings of Slough GB

Teresa De Haro Garcia of Slough GB

Yann Foricher of Paris FR

Helen Tracey Horsley of Slough GB

Martin Clive Hutchings of Slough GB

James Andrew Johnson of Slough GB

Malcolm Maccoss of Seabrook Island SC US

Mengyang Xuan of Slough GB

Zhaoning Zhu of Slough GB

Fused Pentacyclic Imidazole Derivatives as Modulators of TNF Activity

This abstract first appeared for US patent application 18819527 titled 'Fused Pentacyclic Imidazole Derivatives as Modulators of TNF Activity

Original Abstract Submitted

A compound of formula (I) as defined herein, or a pharmaceutically acceptable salt thereof, being potent modulators of human TNFα activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.