18792232. CLAUDIN-6 ANTIBODIES AND DRUG CONJUGATES (THE REGENTS OF THE UNIVERSITY OF CALIFORNIA)

CLAUDIN-6 ANTIBODIES AND DRUG CONJUGATES

Organization Name

THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor(s)

Dylan Conklin of Los Angeles CA (US)

Martina S. Mcdermott of Los Angeles CA (US)

Neil A. O'brien of Los Angeles CA (US)

Michael J. Palazzolo of Los Angeles CA (US)

Dennis Slamon of Los Angeles CA (US)

Erika Von Euw of Los Angeles CA (US)

Peter Bowers of Los Angeles CA (US)

CLAUDIN-6 ANTIBODIES AND DRUG CONJUGATES

This abstract first appeared for US patent application 18792232 titled 'CLAUDIN-6 ANTIBODIES AND DRUG CONJUGATES

Original Abstract Submitted

The present disclosure provides antigen-binding proteins which bind to Claudin-6 (CLDN6). In various aspects, the antigen-binding proteins bind to Extracellular Loop 2 (EL2) of the extracellular domain of CLDN6. Related polypeptides, nucleic acids, vectors, host cells, and conjugates are further provided herein. Kits and pharmaceutical compositions comprising such entities are moreover provided. Also provided are methods of making an antigen-binding protein and methods of treating a subject having cancer.