18732559. EVOLVED CAS9 PROTEINS FOR GENE EDITING (President and Fellows of Harvard College)
EVOLVED CAS9 PROTEINS FOR GENE EDITING
Organization Name
President and Fellows of Harvard College
Inventor(s)
David R. Liu of Cambridge MA US
Johnny Hao Hu of Cambridge MA US
EVOLVED CAS9 PROTEINS FOR GENE EDITING
This abstract first appeared for US patent application 18732559 titled 'EVOLVED CAS9 PROTEINS FOR GENE EDITING
Original Abstract Submitted
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for engineering Cas9 and Cas9 variants that have increased activity on target sequences that do not contain the canonical PAM sequence. In some embodiments, fusion proteins comprising such Cas9 variants and nucleic acid editing domains, e.g., deaminase domains, are provided.
