18730353. Crystalline Salt and Solvate Forms Of Murizatoclax (AMG 397) (AMGEN INC.)
Crystalline Salt and Solvate Forms Of Murizatoclax (AMG 397)
Organization Name
Inventor(s)
Ron C. Kelly of Thousand Oaks CA US
Mary Chaves of Arlington MA US
Jing Teng of Thousand Oaks CA US
Stephan Parent of Thousand Oaks CA US
Van Luu of Thousand Oaks CA US
Robert P. Farrell of Thousand Oaks CA US
James E. Huckle of Thousand Oaks CA US
Michal Achmatowicz of Simi Valley CA US
Darren Leonard Reid of Belmont MA US
Lingyun Xiao of Thousand Oaks CA US
Crystalline Salt and Solvate Forms Of Murizatoclax (AMG 397)
This abstract first appeared for US patent application 18730353 titled 'Crystalline Salt and Solvate Forms Of Murizatoclax (AMG 397)
Original Abstract Submitted
Disclosed herein are salt and solvate forms of (4S,7aR,9aR,10R,11E,14S,15R)-6′-chloro-10-methoxy-14,15-dimethyl-10-{[(9aR)-octahydro-2H-pyrido[1,2-a]pyrazin-2-yl]methyl}-3′,4′,7a,8,9,9a,10,13,14,15-decahydro-2′H,3H,5H-spiro[1,19-etheno-16,16-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadlazacyclohexadecine-4,1 naphthalene]-16,16,18 (7H,17H)-trione (AMG 397): (AMG 397), such as crystalline salt and solvate forms thereof. Also disclosed are methods of making the salt and solvate forms, and methods of treating diseases and disorders with the salt and solvate forms.
- AMGEN INC.
- Ron C. Kelly of Thousand Oaks CA US
- Mary Chaves of Arlington MA US
- Jing Teng of Thousand Oaks CA US
- Stephan Parent of Thousand Oaks CA US
- Van Luu of Thousand Oaks CA US
- Robert P. Farrell of Thousand Oaks CA US
- James E. Huckle of Thousand Oaks CA US
- Michal Achmatowicz of Simi Valley CA US
- Tian Wu of Newbury Park CA US
- Darren Leonard Reid of Belmont MA US
- Lingyun Xiao of Thousand Oaks CA US
- C07D519/00
- A61K31/553
- CPC C07D519/00