18715147. ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER (VANDERBILT UNIVERSITY)
ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
Organization Name
Inventor(s)
Joachim Broeker of Moedling AT
Jason Abbott of Libertyville TN US
Stephen W. Fesik of Nashville TN US
Andrew Little of Sudbury MA US
Andreas Mantoulidis of Vienna AT
Juergen Ramharter of Vienna AT
Christian Alan Paul Smethurst of
Alex Waterson of Murfreesboro TN US
Tobias Wunberg of Hinterbruehl AT
ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
This abstract first appeared for US patent application 18715147 titled 'ANNULATED 2-AMINO-3-CYANO THIOPHENES AND DERIVATIVES FOR THE TREATMENT OF CANCER
Original Abstract Submitted
The present invention encompasses compounds of formula (I), wherein R, R, R, R, Z, Rto R, A, p, L, U, V and W have the meanings given in the claims and specification, their use as inhibitors of mutant Ras family proteins, pharmaceutical compositions and preparations containing such compounds and their use as medicaments/medical uses, especially as agents for treatment and/or prevention of oncological diseases.
- VANDERBILT UNIVERSITY
- Joachim Broeker of Moedling AT
- Jason Abbott of Libertyville TN US
- Jianwen Cui of Franklin TN US
- Stephen W. Fesik of Nashville TN US
- Julian Fuchs of Vienna AT
- Lorenz Herdeis of Vienna AT
- Tim Hodges of Chicago IL US
- Andrew Little of Sudbury MA US
- Andreas Mantoulidis of Vienna AT
- Jason Phan of Nashville TN US
- Juergen Ramharter of Vienna AT
- Dhruba Sarkar of Bangalore IN
- Christian Alan Paul Smethurst of
- Qi Sun of Libertyville IL US
- Matthias Treu of Vienna AT
- Alex Waterson of Murfreesboro TN US
- Birgit Wilding of Vienna AT
- Tobias Wunberg of Hinterbruehl AT
- C07D498/10
- A61K31/506
- A61K31/551
- A61P35/00
- CPC C07D498/10