18715145. KRAS DEGRADING COMPOUNDS COMPRISING ANNULATED 2-AMINO-3-CYANO THIOPHENES (VANDERBILT UNIVERSITY)

KRAS DEGRADING COMPOUNDS COMPRISING ANNULATED 2-AMINO-3-CYANO THIOPHENES

Organization Name

VANDERBILT UNIVERSITY

Inventor(s)

Joachim Broeker of Moedling AT

Jason Abbott of Libertyville IL US

Alessio Ciulli of Dundee GB

Jianwen Cui of Franklin TN US

Emelyne Diers of MoIndal SE

William Farnaby of St.Andrews,Fife GB

Stephen W. Fesik of Nashville TN US

Andreas Gollner of Vienna AT

Jake Goodwin-tindall of Cambridge GB

Tim Hodges of Chicago IL US

Christiane Kofink of Perchtoldsdorf AT

Andrew Little of Sudbury MA US

Andreas Mantoulidis of Vienna AT

Ross Mclennan of Dundee GB

Johannes Popow of Vienna AT

Dhruba Sarkar of Bangalore IN

Martin Schmiedel of Vienna AT

Christian Alan Paul Smethurst of

Nicole Trainor of Melbourne AU

Alex Waterson of Murfreesboro TN US

Harald Weinstabl of Vienna AT

Siying Zhong of Cambridge GB

David Zollman of Dundee GB

KRAS DEGRADING COMPOUNDS COMPRISING ANNULATED 2-AMINO-3-CYANO THIOPHENES

This abstract first appeared for US patent application 18715145 titled 'KRAS DEGRADING COMPOUNDS COMPRISING ANNULATED 2-AMINO-3-CYANO THIOPHENES

Original Abstract Submitted

The present invention relates to compounds and derivatives of formula (I) which target KRAS and can be useful as agents for treatment and/or prevention of oncological diseases.