SUTURE-FREE COAGULATION-ASSISTED FIXED CARDIAC PATCH AND PREPARATION METHOD THEREOF

Organization Name

ZHEJIANG UNIVERSITY

Inventor(s)

Yang Zhu of Hangzhou (CN)

Yuwen Lu of Hangzhou (CN)

Changyou Gao of Hangzhou (CN)

Tanchen Ren of Hangzhou (CN)

Liyin Shen of Hangzhou (CN)

Xiaoqian Hong of Hangzhou (CN)

SUTURE-FREE COAGULATION-ASSISTED FIXED CARDIAC PATCH AND PREPARATION METHOD THEREOF - A simplified explanation of the abstract

This abstract first appeared for US patent application 18695835 titled 'SUTURE-FREE COAGULATION-ASSISTED FIXED CARDIAC PATCH AND PREPARATION METHOD THEREOF

The patent application describes a suture-free coagulation-assisted fixed cardiac patch that includes a polymeric procoagulant base with barbed microneedles fixed on it, creating a microporous structure on the side surface without penetrating the solid base of the polymer.

The included angle between the microneedle and the plane of the polymeric procoagulant base is 60-90°, with microneedles evenly distributed at a density of 5-50 threads/cm2.
The barbs on the microneedles are inclined towards the polymeric procoagulant base, located on the curved surface of the microneedle.
The fabrication method involves using a mold pore-forming technique, a porogen pore-forming method, or a thermally induced phase separation pore-forming process while incorporating the barbed microneedles to create the suture-free coagulation-assisted fixed cardiac patch.

Potential Applications: - Cardiac tissue repair and regeneration - Minimally invasive cardiac surgery - Drug delivery systems for cardiac conditions

Problems Solved: - Eliminates the need for sutures in cardiac patch applications - Provides a secure and stable fixation of the patch - Enhances coagulation and tissue regeneration processes

Benefits: - Reduced risk of infection and inflammation - Improved healing and tissue integration - Simplified surgical procedures

Commercial Applications: "Coagulation-Assisted Fixed Cardiac Patch: Innovations in Cardiac Tissue Repair and Regeneration"

Questions about the technology: 1. How does the microporous structure of the polymeric procoagulant base enhance the performance of the cardiac patch? 2. What are the advantages of using barbed microneedles for fixing the patch compared to traditional sutures?

Original Abstract Submitted

A suture-free coagulation-assisted fixed cardiac patch and fabrication method thereof are provided. The cardiac patch includes a polymeric procoagulant base and a barbed microneedle fixed on the polymeric procoagulant base, and a side surface of the polymeric procoagulant base with the microneedle has a microporous structure which does not penetrate the solid base of the polymer; an included angle α between the microneedle and the plane where the polymeric procoagulant base located is 60-90°, and the microneedles are evenly distributed on the polymeric procoagulant base at a density of 5-50 threads/cm2; the barbs are located on the curved surface of the microneedle and are inclined toward the polymeric procoagulant base. The fabrication method includes using a mold pore-forming, a porogen pore-forming, or a thermally induced phase separation pore-forming, and combining the barbed microneedle while forming the microporous structure to obtain a suture-free coagulation-assisted fixed cardiac patch.