18695673. HETEROCYCLIC COMPOUNDS AND METHODS OF USE (AMGEN INC.)
HETEROCYCLIC COMPOUNDS AND METHODS OF USE
Organization Name
Inventor(s)
Michael M. Yamano of Thousand Oaks CA US
Yunxiao Li of Thousand Oaks CA US
Primali Vasundera Navaratne of Thousand Oaks CA US
Jose M. Medina of Thousand Oaks CA US
Ning Chen of Thousand Oaks CA US
Liping Pettus of Thousand Oaks CA US
Rene Rahimoff of Santa Monica CA US
Xiaofen Li of Thousand Oaks CA US
John Stellwagen of Beverly MA US
Francesco Manoni of Newbury Park CA US
Kexue Li of Newbury Park CA US
Brian Alan Lanman of Woodland Hills CA US
Ryan Paul Wurz of Newbury Park CA US
Josephine Eshon of Medford MA US
HETEROCYCLIC COMPOUNDS AND METHODS OF USE
This abstract first appeared for US patent application 18695673 titled 'HETEROCYCLIC COMPOUNDS AND METHODS OF USE
Original Abstract Submitted
The present disclosure provides compounds useful for the inhibition of KRAS. The compounds have a general Formula I: wherein the variables of Formula I are defined herein. This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, cancer.
- AMGEN INC.
- Michael M. Yamano of Thousand Oaks CA US
- Yunxiao Li of Thousand Oaks CA US
- Primali Vasundera Navaratne of Thousand Oaks CA US
- Jose M. Medina of Thousand Oaks CA US
- Ning Chen of Thousand Oaks CA US
- Liping Pettus of Thousand Oaks CA US
- Rene Rahimoff of Santa Monica CA US
- Xiaofen Li of Thousand Oaks CA US
- John Stellwagen of Beverly MA US
- Francesco Manoni of Newbury Park CA US
- Kexue Li of Newbury Park CA US
- Brian Alan Lanman of Woodland Hills CA US
- Ryan Paul Wurz of Newbury Park CA US
- Wei Zhao of Westford MA US
- Huan Rui of Los Angeles CA US
- Josephine Eshon of Medford MA US
- C07D519/00
- A61K31/519
- A61K31/5386
- A61K31/541
- A61K31/553
- A61K31/554
- C07D471/04
- CPC C07D519/00
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