DELIVERY OF ANITSENSE OLIGOMERS BY MIRROR IMAGE PEPTIDES

Organization Name

Massachusetts Institute of Technology

Inventor(s)

Carly K. Schissel of Cambridge MA (US)

Charlotte E. Farquhar of Cambridge MA (US)

Annika B. Malmberg of Cambridge MA (US)

Andrei Loas of Cambridge MA (US)

Bradley L. Pentelute of Cambridge MA (US)

DELIVERY OF ANITSENSE OLIGOMERS BY MIRROR IMAGE PEPTIDES

This abstract first appeared for US patent application 18688144 titled 'DELIVERY OF ANITSENSE OLIGOMERS BY MIRROR IMAGE PEPTIDES

Original Abstract Submitted

Provided herein are oligonucleotides, cell-penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.