18641299. ADENOSINE NUCLEOBASE EDITORS AND USES THEREOF (President and Fellows of Harvard College)

ADENOSINE NUCLEOBASE EDITORS AND USES THEREOF

Organization Name

President and Fellows of Harvard College

Inventor(s)

David R. Liu of Cambridge MA US

Nicole Gaudelli of Cambridge MA US

ADENOSINE NUCLEOBASE EDITORS AND USES THEREOF

This abstract first appeared for US patent application 18641299 titled 'ADENOSINE NUCLEOBASE EDITORS AND USES THEREOF

Original Abstract Submitted

The disclosure provides adenosine deaminases that are capable of deaminating adenosine in DNA. The disclosure also provides fusion proteins comprising a Cas9 (e.g., a Cas9 nickase) domain and adenosine deaminases that deaminate adenosine in DNA. In some embodiments, the fusion proteins further comprise a nuclear localization sequence (NLS), and/or an inhibitor of base repair, such as, a nuclease dead inosine specific nuclease (dISN).