HUMAN MESOTHELIN CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

Organization Name

Novartis AG

Inventor(s)

Gregory Beatty of Philadelphia PA (US)

Boris Engels of Arlington MA (US)

Neeraja Idamakanti of Burlington MA (US)

Carl H. June of Merion Station PA (US)

Andreas Loew of Boston MA (US)

Huijuan Song of Shanghai (CN)

Qilong Wu of Brighton MA (US)

HUMAN MESOTHELIN CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

This abstract first appeared for US patent application 18609414 titled 'HUMAN MESOTHELIN CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF

Original Abstract Submitted

Provided are compositions and methods for treating diseases associated with expression of mesothelin. Also provided are a chimeric antigen receptor (CAR) specific to mesothelin, vectors encoding the same, and recombinant T cells comprising the mesothelin CAR. Further provided are methods of administering a genetically modified T cell expressing a CAR that comprises a mesothelin binding domain.