18442444. Non-Human Animals Expressing Humanized CD3 Complex simplified abstract (Regeneron Pharmaceuticals, Inc.)

Non-Human Animals Expressing Humanized CD3 Complex

Organization Name

Regeneron Pharmaceuticals, Inc.

Inventor(s)

Kara L. Olson of White Plains NY (US)

Eric Smith of New York NY (US)

Ka-Man Venus Lai of Seattle WA (US)

Andrew J. Murphy of Croton-on-Hudson NY (US)

Gavin Thurston of Millerton NY (US)

Dayong Guo of Overland Park KS (US)

Non-Human Animals Expressing Humanized CD3 Complex - A simplified explanation of the abstract

This abstract first appeared for US patent application 18442444 titled 'Non-Human Animals Expressing Humanized CD3 Complex

Simplified Explanation

This patent application discusses the creation of non-human animals with humanized CD3 proteins in their genome, as well as methods for making and using these animals.

Key Features and Innovation

• Creation of non-human animals expressing humanized CD3 proteins.
• Genetic modification of rodents to include humanized CD3 proteins in their genome.
• Methods and compositions for making these animals.
• Methods for utilizing these animals in research and other applications.

Potential Applications

The technology could be used in various research fields, such as immunology, drug development, and disease modeling.

Problems Solved

This technology allows for the study of human immune responses in a more accurate and relevant animal model, potentially leading to advancements in medical research and treatment development.

Benefits

• Enhanced understanding of human immune system responses.
• Improved drug testing and development processes.
• Potential for more effective disease modeling.

Commercial Applications

The technology could have commercial applications in pharmaceutical research, biotechnology, and medical device development.

Prior Art

Researchers may want to explore prior studies on humanized animal models and CD3 proteins in the context of immunology and medical research.

Frequently Updated Research

Stay informed about the latest advancements in humanized animal models and their applications in medical research and drug development.

Questions about Non-Human Animals Expressing Humanized CD3 Proteins

What are the potential implications of using non-human animals with humanized CD3 proteins in medical research?

Non-human animals expressing humanized CD3 proteins can provide more accurate and relevant models for studying human immune responses, potentially leading to significant advancements in medical research and treatment development.

How do researchers ensure the ethical treatment of genetically modified animals in these studies?

Researchers must adhere to strict ethical guidelines and regulations to ensure the humane treatment of genetically modified animals in research studies.

Original Abstract Submitted

Non-human animals, expressing humanized CD3 proteins are provided. Non-human animals, e.g., rodents, genetically modified to comprise in their genome humanized CD3 proteins are also provided. Additionally, provided are methods and compositions of making such non-human animals, as well as methods of using said non-human animals.