18437259. ANALYSIS METHOD OF CARBOXYLIC ACID ANHYDRIDE simplified abstract (SHIMADZU CORPORATION)
ANALYSIS METHOD OF CARBOXYLIC ACID ANHYDRIDE
Organization Name
Inventor(s)
Hidetoshi Terada of Kyoto (JP)
ANALYSIS METHOD OF CARBOXYLIC ACID ANHYDRIDE - A simplified explanation of the abstract
This abstract first appeared for US patent application 18437259 titled 'ANALYSIS METHOD OF CARBOXYLIC ACID ANHYDRIDE
- Simplified Explanation:**
The patent application describes a method for analyzing a sample containing a carboxylic acid anhydride using supercritical fluid chromatography. The method involves passing the sample through a column with different mobile phases to detect various compounds.
- Key Features and Innovation:**
- Utilizes supercritical fluid chromatography for analyzing carboxylic acid anhydrides - Switches between different mobile phases to detect different compounds in the sample - First mobile phase is a mixture of carbon dioxide and an organic solvent without a hydroxyl group - Second mobile phase is a mixture of carbon dioxide, an acid, and an organic solvent with a hydroxyl group
- Potential Applications:**
- Chemical analysis in research laboratories - Quality control in pharmaceutical industries - Environmental monitoring for carboxylic acid compounds
- Problems Solved:**
- Efficient separation and detection of carboxylic acid anhydrides - Improved accuracy in identifying related compounds in a sample - Enhanced sensitivity in detecting trace amounts of carboxylic acid derivatives
- Benefits:**
- Faster and more accurate analysis of samples - Increased sensitivity for detecting compounds - Versatile method for various applications in different industries
- Commercial Applications:**
- "Supercritical Fluid Chromatography Method for Carboxylic Acid Anhydride Analysis" can be used in pharmaceutical companies for drug development and quality control processes. This technology can also find applications in environmental testing laboratories for monitoring carboxylic acid compounds in water and soil samples.
- Questions about the Technology:**
1. How does the use of supercritical fluid chromatography improve the analysis of carboxylic acid anhydrides compared to traditional methods? 2. What are the specific advantages of switching between different mobile phases in detecting various compounds in the sample?
Original Abstract Submitted
A method for analyzing a sample containing a carboxylic acid anhydride includes, in a stated order, a first step of causing the sample to pass through a column together with a first mobile phase to detect a carboxylic acid anhydride eluted from the column in supercritical fluid chromatography, and a second step of causing a second mobile phase to pass through the column by switching the mobile phase from the first mobile phase to the second mobile phase after a lapse of a retention time of the carboxylic acid anhydride to detect at least one of a carboxylic acid ester and a carboxylic acid eluted from the column. The first mobile phase is a mixture of carbon dioxide and an organic solvent having no hydroxyl group, and the second mobile phase is a mixture of carbon dioxide, an acid, and an organic solvent having a hydroxyl group.