18433538. METHODS OF CANCER TREATMENT VIA REGULATED FERROPTOSIS (CORNELL UNIVERSITY)
METHODS OF CANCER TREATMENT VIA REGULATED FERROPTOSIS
Organization Name
Inventor(s)
Michelle S. Bradbury of Ithaca NY (US)
Michael Overholtzer of Glen Ridge NJ (US)
Howard Scher of Tenafly NJ (US)
Ulrich Wiesner of Ithaca NY (US)
Brian Madajewski of New York NY (US)
METHODS OF CANCER TREATMENT VIA REGULATED FERROPTOSIS
This abstract first appeared for US patent application 18433538 titled 'METHODS OF CANCER TREATMENT VIA REGULATED FERROPTOSIS
Original Abstract Submitted
The present disclosure describes methods of treatment (e.g., combination treatment) by ferroptotic induction, as well as compositions and dosing regimens that are part of such methods. Surprisingly, it is presently found that delaying administration of a ferroptosis-inducing agent until after starting hormone therapy results in enhanced ferroptotic induction in a subject. Thus, in certain embodiments, combination therapies are presented herein that include multiple administration steps whereby a ferroptosis-inducing agent is administered some time after hormone therapy has begun.