MULTIPLEXED NUCLEIC ACID AMPLIFICATION TEST ON SEMICONDUCTOR SUBSTRATE

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MULTIPLEXED NUCLEIC ACID AMPLIFICATION TEST ON SEMICONDUCTOR SUBSTRATE

This abstract first appeared for US patent application 18428825 titled 'MULTIPLEXED NUCLEIC ACID AMPLIFICATION TEST ON SEMICONDUCTOR SUBSTRATE

Original Abstract Submitted

Example packaged integrated circuit (IC) sensors comprise a semiconductor substrate; a back end of line (BEOL) structure on the semiconductor substrate, the BEOL structure including multiple microfluidic channels, each microfluidic channel including a flow control device configured to selectively permit and restrict flow of fluids; multiple fluid sensors including first and second fluid sensors in the BEOL structure; a main reaction reservoir on the BEOL structure configured to store a reagent, in which the reagent is operable to replicate a nucleic strand in a biological sample to cause a pH change, and the first fluid sensor is exposed in the main reaction reservoir; an auxiliary reservoir on the BEOL structure and coupled to the main reaction reservoir via a microfluid channel of the multiple microfluidic channels, in which the second fluid sensor is exposed in the auxiliary reaction reservoir; and a controller coupled to the first and second fluid sensors.