18274133. PHOTO-CROSSLINKED BIOREDUCIBLE POLYMERIC NANOPARTICLES FOR ENHANCED RNA DELIVERY (The Johns Hopkins University)

PHOTO-CROSSLINKED BIOREDUCIBLE POLYMERIC NANOPARTICLES FOR ENHANCED RNA DELIVERY

Organization Name

The Johns Hopkins University

Inventor(s)

Jordan J. Green of Woodstock MD (US)

Johan Karlsson of Baltimore MD (US)

Stephany Yi Tzeng of Somerville MD (US)

Kathryn M. Luly of Baltimore MD (US)

Yuan Rui of Baltimore MD (US)

David Wilson of Smithsburg MD (US)

Kristen Kozielski of Baltimore MD (US)

PHOTO-CROSSLINKED BIOREDUCIBLE POLYMERIC NANOPARTICLES FOR ENHANCED RNA DELIVERY

This abstract first appeared for US patent application 18274133 titled 'PHOTO-CROSSLINKED BIOREDUCIBLE POLYMERIC NANOPARTICLES FOR ENHANCED RNA DELIVERY

Original Abstract Submitted

Nanocarriers are engineered to realize the potential of RNA therapeutics. This work reports the design of pho-to-crosslinked bioreducible nanoparticles (XbNPs) for stable siRNA encapsulation in high serum conditions, shielded surface charge, efficient intracellular trafficking, and triggered cytosolic RNA release. These attributes of XbNPs leads to robust siRNA-mediated knockdown in cancer cells and potent systemic siRNA delivery to tumors in the lungs.