10x Genomics, Inc. (20240254552). PROBE-BASED ANALYSIS OF NUCLEIC ACIDS AND PROTEINS

PROBE-BASED ANALYSIS OF NUCLEIC ACIDS AND PROTEINS

Organization Name

10x Genomics, Inc.

Inventor(s)

Katherine Pfeiffer of San Francisco CA US

Andrew Scott Kohlway of Dublin CA US

Andrew John Hill of Seattle WA US

Paul Eugene Lund of San Leandro CA US

Jawad N. Abousoud of Pleasanton CA US

Sharmila Chatterjee Bhattacharjee of San Jose CA US

Ryan Stott of Oakland CA US

PROBE-BASED ANALYSIS OF NUCLEIC ACIDS AND PROTEINS

This abstract first appeared for US patent application 20240254552 titled 'PROBE-BASED ANALYSIS OF NUCLEIC ACIDS AND PROTEINS

Original Abstract Submitted

provided herein are systems and methods for processing biomolecules (e.g., nucleic acid molecules, proteins) from a sample. a method for processing biomolecules may comprise hybridizing a probe molecule to a target region of a nucleic acid molecule (e.g., a ribonucleic acid (rna) molecule) and barcoding the probe-nucleic acid molecule complex or derivatives thereof. such a method can comprise performing a nucleic acid reaction, e.g., extension, denaturation, and amplification. a method for processing a sample may comprise hybridizing probes to (i) target regions of a nucleic acid molecule (e.g., rna molecule) and (ii) a reporter oligonucleotide of a feature binding group, and barcoding the probe-associated molecules. one or more processes of the methods described herein may be performed within a partition, such as a droplet or well.