The Regents of the University of California patent applications on August 1st, 2024
Patent Applications by The Regents of the University of California on August 1st, 2024
The Regents of the University of California: 30 patent applications
The Regents of the University of California has applied for patents in the areas of A61K39/00 (4), A61K45/06 (3), A61K38/00 (2), A61B5/00 (2), C12N15/10 (2) A61B5/0261 (1), C22C29/14 (1), H01S5/34333 (1), H01M10/0565 (1), H01M10/0562 (1)
With keywords such as: methods, comprising, device, layer, sensor, based, provided, array, circular, and disclosed in patent application abstracts.
Patent Applications by The Regents of the University of California
Inventor(s): Wenjun Zhou of Davis CA (US) for the regents of the university of california, Oybek Kholiqov of Davis CA (US) for the regents of the university of california, Vivek Jay Srinivasan of Davis CA (US) for the regents of the university of california
IPC Code(s): A61B5/026, A61B5/00
CPC Code(s): A61B5/0261
Abstract: the disclosed embodiments provide a system that non-invasively analyzes blood flow in a sample of living tissue. during operation, the system obtains light from a temporally coherent source, and splits the obtained light between a reference path and a sample path. next, the system multiply scatters light from the sample path by passing the light through the sample. the system then recombines light from the reference path and the multiply scattered light from the sample path. next, the system uses a sensor array to detect an interference pattern resulting from the recombination. finally, the system analyzes signals from the sensor array to determine a blood flow in the sample.
Inventor(s): Liangfang Zhang of San Diego CA (US) for the regents of the university of california, Che-Ming (Jack) Hu of San Diego CA (US) for the regents of the university of california, Ronnie Hongbo Fang of Irvine CA (US) for the regents of the university of california, Jonathan Copp of La Jolla CA (US) for the regents of the university of california
IPC Code(s): A61K9/14, A61K39/00, A61K39/085, A61K39/39, A61K45/06
CPC Code(s): A61K9/148
Abstract: provided are nanoparticles and methods of using and making thereof. the inventive nanoparticle comprises a) an inner core comprising a non-cellular material; and b) an outer surface comprising a cellular membrane derived from a cell or a membrane derived from a virus. medicament delivery systems or pharmaceutical compositions comprising the inventive nanoparticles are also provided. further provided are immunogenic compositions comprising the inventive nanoparticles, and methods of using the inventive immunogenic compositions for eliciting an immune response, and for treating or preventing diseases or condition, such as neoplasm or cancer, or disease or conditions associated with cell membrane inserting toxin. vaccines comprising the immunogenic composition comprising the nanoparticles are also provided.
Inventor(s): Daniele Piomelli of Irvine CA (US) for the regents of the university of california, Yannick Fotio of Irvine CA (US) for the regents of the university of california
IPC Code(s): A61K31/496, A61K31/164, A61K31/196, A61K31/222, A61K31/337, A61K31/55, A61K45/06, A61P29/00
CPC Code(s): A61K31/496
Abstract: disclosed herein, inter alia, are methods of stimulating mitochondrial respiration and methods of treating pain.
Inventor(s): Vaithilingaraja Arumugaswami of Woodland Hills CA (US) for the regents of the university of california, Gustavo Garcia Jr. of Gardena CA (US) for the regents of the university of california, Kouki Morizono of Los Angeles CA (US) for the regents of the university of california
IPC Code(s): A61K39/215, A61K39/00, A61P31/14, C12N7/00
CPC Code(s): A61K39/215
Abstract: disclosed herein are nucleic acid constructs comprising a replication defective zika virus vector and one or more coronavirus sequences and compositions thereof. the constructs relates to compositions and methods for inducing an immune response against coronavirus antigens due to the severe acute respiratory syndrome coronavirus 2 (sars-cov-2) outbreak. the results herein indicate that these coronavirus constructs are safe and will induce an immune response that may provide protection against coronaviruses.
Inventor(s): Lei Wang of San Francisco CA (US) for the regents of the university of california, Shanshan Li of San Francisco CA (US) for the regents of the university of california
IPC Code(s): A61K47/54, A61K38/00, C07D207/416, C07K14/705, C12N9/00, C12Q1/6886
CPC Code(s): A61K47/545
Abstract: provided herein are, inter alia, compounds of formula (i): biomolecules (e.g., proteins, lipids, rna, glycans) comprising the compounds; bioconjugates comprising the compounds; processes for preparing the compounds, biomolecules, and bioconjugates; and their uses.
Inventor(s): Lei Wang of San Francisco CA (US) for the regents of the university of california, Shanshan Li of San Francisco CA (US) for the regents of the university of california
IPC Code(s): A61K47/54, A61K38/00, C07D207/416, C07K14/705, C12N9/00, C12Q1/6886
CPC Code(s): A61K47/545
Abstract:
Inventor(s): Orian SHIRIHAI of Los Angeles CA (US) for the regents of the university of california, Mark GRINSTAFF of Brookline MA (US) for the regents of the university of california, Jialiu ZENG of Singapore (SG) for the regents of the university of california
IPC Code(s): A61K47/69, A61K9/00, A61K47/55, A61P3/04, A61P3/10, A61P25/28, B82Y5/00
CPC Code(s): A61K47/6935
Abstract: in various embodiments novel biodegradable acid-activated acid releasing nanoparticles (acnps) are provided that are used as a targeted strategy to manipulate lysosomal acidity and autophagy. these acnps based, in certain embodiments, on fluorinated polyesters are degraded at ph 6.0 (ph reported in dysfunctional lysosomes), and release component acids that further lower the lysosomal ph, and thereby increasing autophagic flux and cellular function of hepatocytes under lt. the acnps can serve as a therapeutic in restoring liver-diseases.
Inventor(s): Varghese John of San Francisco CA (US) for the regents of the university of california, Jesus Campagna of Playa Del Rey CA (US) for the regents of the university of california
IPC Code(s): A61K48/00, A61K9/127, A61K38/17, C12N9/22, C12N9/80, C12N15/11, C12N15/88
CPC Code(s): A61K48/0041
Abstract: this invention provides synthetic exosomes that contain and deliver an effective amount of a gene editor. in certain embodiments the synthetic exosome comprises a liposome formed from a lipid bilayer, where said lipid bilayer comprises: one or more phospholipids selected from the group consisting of phosphate lipids, phosphoglycerol lipids, phosphocholine lipids, and phosphoethanolamine lipids where the lipid carbon chain ranges from 3 to 24 carbon atoms: cholesterol, a cholesterol derivative, or a phytosterol; and a non-ionic surfactant; where the lipid bilayer does not contain an alcohol: the exosome is less than about 200 nm in diameter; and the exosome contains a guide rna (grna) and a cytidine base editor, where the grna comprise a sequence that directs said n-cas9-cytidine deaminase to edit the codon for amino acid 112 of the gene encoding apoe4.
Inventor(s): Scott Mitchell Fishman of Sacramento CA (US) for the regents of the university of california, Nathan Galen Rosecrans of Sacramento CA (US) for the regents of the university of california
IPC Code(s): A61M5/32
CPC Code(s): A61M5/329
Abstract: devices and methods for bending a medical or surgical instrument are disclosed. a device may include a handle and a bending die. a first end of the bending die may be coupled to the handle. a recess may be formed partially or entirely in a second end of the bending die. the recess may be configured to permit a portion or an entirety of the medical or surgical instrument to be inserted laterally into the bending die. a method may include laterally inserting the medical or surgical instrument into the bending die and rotating the bending die with respect to the medical or surgical instrument to press the medical or surgical instrument against the bending die to form one or more bends in the medical or surgical instrument.
Inventor(s): Steven A. GOLDSTEIN of Irvine CA (US) for the regents of the university of california, Ruiming Zhao of Irvine CA (US) for the regents of the university of california
IPC Code(s): C07K7/06, A61K38/00, A61P11/00, A61P37/06
CPC Code(s): C07K7/06
Abstract: in alternative embodiments, provided are compositions, including products of manufacture and kits, and methods, for inhibiting the ability of neutrophils, or polymorphonuclear leukocytes (pmns), to release reactive oxygen species (ros), thus also inhibiting or ameliorating neutrophil (pmn) contribution to an inflammatory response, thus also treating, ameliorating or preventing neutrophil (pmn)-meditated inflammatory-related pathologies such as acute respiratory distress syndrome (ards), including ards caused by a viral infection such as covid-19.
Inventor(s): Bin LIU of San Francisco CA (US) for the regents of the university of california, Nam-Kyung LEE of Daejeon (KR) for the regents of the university of california, Scott BIDLINGMAIER of San Francisco CA (US) for the regents of the university of california, Yang SU of South San Francisco CA (US) for the regents of the university of california
IPC Code(s): C07K16/28, A61K39/00, A61P19/10, C12N15/10
CPC Code(s): C07K16/28
Abstract: antibodies are provided herein that agonize wnt signaling, do not compete with a wnt ligand for lrp6 binding, and activate wnt signaling in the presence of inhibitors. methods for promoting cell differentiation and tissue regeneration using the disclosed antibodies are also provided.
Inventor(s): Alysson Renato Muotri of San Diego CA (US) for the regents of the university of california
IPC Code(s): C12N5/0797, A61K35/30
CPC Code(s): C12N5/0623
Abstract: the disclosure is directed to a method to generate glial restricted neural progenitor cells (grnpcs), and uses thereof, including for the treatment of neurological or neurodegenerative disorders.
Inventor(s): Neal Devaraj of La Jolla CA (US) for the regents of the university of california, Dongyang Zhang of La Jolla CA (US) for the regents of the university of california
IPC Code(s): C12N15/11, C07H21/02, C12N9/10
CPC Code(s): C12N15/11
Abstract: provided herein are, inter alia, methods and compositions for linking rna stem loops. the methods include linking a first rna stem loop and a second rna stem loop by way of a preq1 linking compound.
Inventor(s): Richard B. KANER of Pacific Palisades CA (US) for the regents of the university of california, Christopher L. TURNER of Lancaster CA (US) for the regents of the university of california, Madapusi K. KESHAVAN of Oceanside CA (US) for the regents of the university of california, Jack KAVANAUGH of Los Angeles CA (US) for the regents of the university of california
IPC Code(s): C22C29/14, B24D18/00, C22C1/051, C22C1/10, C22C29/08, C22C32/00, C22C33/02
CPC Code(s): C22C29/14
Abstract: disclosed herein, in certain embodiments, are composite materials, methods, tools and abrasive materials comprising a tungsten-based metal composition, a tungsten carbide, and an alloy. in some cases, the composite materials or matrix are resistant to oxidation.
Inventor(s): Gaurav Sant of Los Angeles CA (US) for the regents of the university of california, Dante Adam Simonetti of Los Angeles CA (US) for the regents of the university of california, Xin Chen of Los Angeles CA (US) for the regents of the university of california, David Jassby of Los Angeles CA (US) for the regents of the university of california, Erika Callagon La Plante of Los Angeles CA (US) for the regents of the university of california, Steven Bustillos of Los Angeles CA (US) for the regents of the university of california, Thomas J. Traynor of Los Angeles CA (US) for the regents of the university of california
IPC Code(s): C25B11/077, B01D53/32, B01D53/62, C01G51/00, C01G55/00, C25B1/14, C25B11/075
CPC Code(s): C25B11/0775
Abstract: the present disclosure relates to oxygen-selective anodes and methods for the use thereof.
Inventor(s): Edward C. Kuan of Orange CA (US) for the regents of the university of california, Michelle Khine of Irvine CA (US) for the regents of the university of california, Andrej Luptak of Irvine CA (US) for the regents of the university of california, Arash Abiri of Irvine CA (US) for the regents of the university of california, Julia A. Zakashansky of Irvine CA (US) for the regents of the university of california, Xinlei Chen of Irvine CA (US) for the regents of the university of california
IPC Code(s): G01N27/327, C12N15/115, G16C20/20
CPC Code(s): G01N27/3277
Abstract: a portable device for detection of cerebrospinal fluid (csf) in a sample. the device may comprise a substrate and a sensor disposed on the substrate, the sensor comprising a sensing area. the sensor further comprises an aptamer solution comprising an aptamer sequence functionalized by a redox agent to be sensitive to the csf biomarker and functionalized to attach to the sensor. the sensor may be configured to be sensitive to a csf biomarker. the device may further comprise an electrochemical detection component operatively coupled to the sensor. when a sample containing an amount of the csf biomarker is disposed on the sensing area of the sensor, the electrode may generate a detection signal to be transmitted to the electrochemical detection component. the electrochemical detection component may transmit the detection signal to the computing device.
Inventor(s): Sheng XU of La Jolla CA (US) for the regents of the university of california, Yue GU of La Jolla CA (US) for the regents of the university of california
IPC Code(s): G01N27/414, G01N33/50
CPC Code(s): G01N27/4148
Abstract: a method for fabricating a three-dimensional (3d) fet sensor array includes fabricating a two-dimensional (2d) precursor field-effect transistor (fet) sensor array having a plurality of nanoscale or microscale fets using any suitable microfabrication techniques. each of the nanoscale or microscale fets have a kink at which a fet channel is located. the 2d nanoscale or microscale precursor fet sensor array is caused to buckle or fold into a third dimension, also using any suitable technique.
Inventor(s): Aydogan Ozcan of Los Angeles CA (US) for the regents of the university of california, Hyou-Arm Joung of Los Angeles CA (US) for the regents of the university of california, Yi Luo of Los Angeles CA (US) for the regents of the university of california
IPC Code(s): G01N33/68, G01N15/075, G01N33/543, G06T7/00, G06V10/762, G06V10/82, G06V20/69
CPC Code(s): G01N33/6893
Abstract: a quantitative particle agglutination assay device is disclosed that combines portable lens-free microscopy and deep learning for rapidly measuring the concentration of a target analyte. as one example of a target analyte, the assay device was used to test for high-sensitivity c-reactive protein (hs-crp) using human serum samples. a dual-channel capillary lateral flow device is designed to host the agglutination reaction using a small volume of serum. a portable lens-free microscope records time-lapsed inline holograms of the lateral flow device, monitoring the agglutination process over several minutes. these captured holograms are processed, and at each frame the number and area of the particle clusters are automatically extracted and fed into shallow neural networks to predict the crp concentration. the system can be used to successfully differentiate very high crp concentrations (e.g., >10-500 �g/ml) from the hs-crp range.
Inventor(s): Daniel J. Blumenthal of Santa Barbara CA (US) for the regents of the university of california, Matt Eichenfield of Albuquerque NM (US) for the regents of the university of california, Dirk Englund of Cambridge MA (US) for the regents of the university of california, Mikkel Heuck of Cambridge MA (US) for the regents of the university of california
IPC Code(s): G02B6/122
CPC Code(s): G02B6/1228
Abstract: systems and methods for hybrid integration of ultra-low loss waveguide photonic circuits with various efficient on-chip elements are described. the photonic circuits can integrate various elements including (but not limited to): gain, modulation, detection, and nonlinear optical elements. the integrated photonic chips can be manufactured in a flexible, reconfigurable, 3d heterogeneous platform. the integrated photonic chips can cover wavelength ranges from the visible wavelength to infrared wavelength.
Inventor(s): Daniel J. Blumenthal of Santa Barbara CA (US) for the regents of the university of california, Jiawei Wang of Goleta CA (US) for the regents of the university of california, Kaikai Liu of Santa Barbara CA (US) for the regents of the university of california, Ryan Q. Rudy of Adelphi MD (US) for the regents of the university of california
IPC Code(s): G02B26/08, G02B6/42, H10N30/20, H10N30/853, H10N30/87
CPC Code(s): G02B26/0875
Abstract: disclosed herein is a stress optical modulator. the modulator include a circular piezo-electric actuator; and a ring waveguide separated from the circular piezo-electric actuator by a top cladding layer. the circular piezo-electric actuator may be offset from the ring waveguide such that a first circular portion of the circular piezo-electric actuator is located on the outside of the ring waveguide and a second circular portion of the circular piezo-electric actuator is located on the inside of the ring waveguide. the circular piezo-electric actuator may be configured to change the guiding properties of the ring waveguide based on the voltage applied to the circular piezo-electric actuator by inducing strain through the top cladding layer to change the optical properties of the ring waveguide.
Inventor(s): Dan Wang of Berkeley CA (US) for the regents of the university of california, Qiang Du of Pleasanton CA (US) for the regents of the university of california, Russell Wilcox of Berkeley CA (US) for the regents of the university of california, Tong Zhou of Albany CA (US) for the regents of the university of california, Christos Bakalis of Berkeley CA (US) for the regents of the university of california, Derun Li of Concord CA (US) for the regents of the university of california
IPC Code(s): G06N3/08
CPC Code(s): G06N3/08
Abstract: a machine learning (ml) controller and method for systems that can learn to stabilize them based on measurements of an unstable system. this allows for training on a system not yet controlled and for continuous learning as the stabilizer operates. the controller has improved performance on unstable systems compared to similar technologies, especially complex ones with many inputs and outputs. furthermore, there is no need for modelling the physics, and the controller can adapt to un-analyzed or partially analyzed systems.
Inventor(s): Lawrence R. Frank of San Diego CA (US) for the regents of the university of california, Vitaly L. Galinsky of San Diego CA (US) for the regents of the university of california
IPC Code(s): G06V10/77, A61B5/00, A61B5/055, G01R33/48, G01R33/56, G01R33/563, G06F18/2135, G06F18/2413, G06T7/00
CPC Code(s): G06V10/7715
Abstract: analysis of complex spatio-temporal data within a dynamic system that includes spatial positions and fields, at least a portion of which are interacting, includes determining values of mean field at every spatial position, determining spatio-temporal eigenmodes in spatial-frequency space assuming interacting fields, and determining spatial and temporal interactions between the eigenmodes. the resulting display indicates space/time localization patterns that are indicative of connectivity within the dynamic system.
Inventor(s): Gerbrand Ceder of Berkeley CA (US) for the regents of the university of california, Jianping Huang of Berkeley CA (US) for the regents of the university of california
IPC Code(s): H01M4/505, C01G31/00, C01G45/12, H01M4/62
CPC Code(s): H01M4/505
Abstract: a lithium rich partially cation disordered transition metal oxide cathode material is provided that exhibits reduced voltage hysteresis, reduced or inhibited transition metal migration and increased capacity and energy storage compared with layered oxides. the lithium rich cathode material is based on licrmowhere m is a transition metal with limited redox activity, such as mn, ti, zr, sn, nb, ta, and w, and where 0<x<0.33 and 0<y<0.67. cation disordering is induced in the material that alters both the structure and the electrochemistry and effectively mitigate voltage hysteresis and increase the reversibility of the cr/cr redox couple and the energy capacity. lithium transport in the cation-disordered structure occurs through a percolation network of li-rich tetrahedral environments.
Inventor(s): Seamus D. Jones of Goleta CA (US) for the regents of the university of california, Yanqiao Chen of Goleta CA (US) for the regents of the university of california, Peter Richardson of Santa Barbara CA (US) for the regents of the university of california, Raphaele Clement of Santa Barbara CA (US) for the regents of the university of california, Craig J. Hawker of Santa Barbara CA (US) for the regents of the university of california, Glenn H. Fredrickson of Santa Barbara CA (US) for the regents of the university of california, Rachel A. Segalman of Santa Barbara CA (US) for the regents of the university of california
IPC Code(s): H01M10/0565
CPC Code(s): H01M10/0565
Abstract: a solid electrolyte including zwitterionic compounds comprising zwitterionic molecules and/or charge neutral polymers with zwitterion pendants. a salt is distributed through the solid such that the solid conducts alkali metal ions obtained from the salt and the zwitterionic compounds each include zero or more amorphous regions and one or more crystalline regions characterized by (1) a presence of bragg diffraction peaks in an x-ray diffraction measurement of the solid; and (2) the solid having an ion conductivity of at least 10s/cm at a temperature of 50 degrees celsius when a transport number for the alkali metal ions is at least 0.5 and a molar ratio of the salt to the zwitterionic units is 0.9. the electrolyte exhibits surprisingly high alkali metal ion conductivity and linear elastic modulus over a wide range of practically useful temperatures.
Inventor(s): Philip Chan of Goleta CA (US) for the regents of the university of california, Steven P. DenBaars of Goleta CA (US) for the regents of the university of california, Shuji Nakamura of Santa Barbara CA (US) for the regents of the university of california
IPC Code(s): H01S5/343, H01S5/20
CPC Code(s): H01S5/34333
Abstract: a iii-nitride based device is fabricated having an in-plane lattice constant or strain that is more than 30% biaxially relaxed, by creating a iii-nitride based decomposition stop layer on or above a iii-nitride based decomposition layer, wherein a temperature is increased to decompose the iii-nitride based decomposition layer; and growing a iii-nitride based device structure on or above the iii-nitride based decomposition stop layer. the iii-nitride based device structure includes at least one of an n-type layer, active layer, and p-type layer, and at least one of the n-type layer, active layer and p-type layer has an in-plane lattice constant or strain that is preferably more than 30% biaxially relaxed, more preferably 50% or more biaxially relaxed, and most preferably at least 70% biaxially relaxed.
Inventor(s): Robert Dynes of La Jolla CA (US) for the regents of the university of california, Uday Goteti of San Diego CA (US) for the regents of the university of california
IPC Code(s): H10N60/12, G06N3/063, G06N10/40, H10N60/80, H10N69/00
CPC Code(s): H10N60/12
Abstract: methods, systems, and devices for neural networks and neuromorphic computing are disclosed. in one implementation, a neural network includes an array of superconducting loops to store information, the superconducting loops multiply coupled to each other inductively or through josephson junctions linking the superconducting loops, one or more input channels coupled to the array of superconducting loops to carry spiking input voltage signals to the array of superconducting loops, and one or more output channels coupled to the array of superconducting loops to carry spiking output voltage signals from the array of superconducting loops.
The Regents of the University of California patent applications on August 1st, 2024
- The Regents of the University of California
- A61B5/026
- A61B5/00
- CPC A61B5/0261
- The regents of the university of california
- A61K9/14
- A61K39/00
- A61K39/085
- A61K39/39
- A61K45/06
- CPC A61K9/148
- A61K31/496
- A61K31/164
- A61K31/196
- A61K31/222
- A61K31/337
- A61K31/55
- A61P29/00
- CPC A61K31/496
- A61K39/215
- A61P31/14
- C12N7/00
- CPC A61K39/215
- A61K47/54
- A61K38/00
- C07D207/416
- C07K14/705
- C12N9/00
- C12Q1/6886
- CPC A61K47/545
- A61K47/69
- A61K9/00
- A61K47/55
- A61P3/04
- A61P3/10
- A61P25/28
- B82Y5/00
- CPC A61K47/6935
- A61K48/00
- A61K9/127
- A61K38/17
- C12N9/22
- C12N9/80
- C12N15/11
- C12N15/88
- CPC A61K48/0041
- A61M5/32
- CPC A61M5/329
- C07K7/06
- A61P11/00
- A61P37/06
- CPC C07K7/06
- C07K16/28
- A61P19/10
- C12N15/10
- CPC C07K16/28
- C12N5/0797
- A61K35/30
- CPC C12N5/0623
- C07H21/02
- C12N9/10
- CPC C12N15/11
- C22C29/14
- B24D18/00
- C22C1/051
- C22C1/10
- C22C29/08
- C22C32/00
- C22C33/02
- CPC C22C29/14
- C25B11/077
- B01D53/32
- B01D53/62
- C01G51/00
- C01G55/00
- C25B1/14
- C25B11/075
- CPC C25B11/0775
- G01N27/327
- C12N15/115
- G16C20/20
- CPC G01N27/3277
- G01N27/414
- G01N33/50
- CPC G01N27/4148
- G01N33/68
- G01N15/075
- G01N33/543
- G06T7/00
- G06V10/762
- G06V10/82
- G06V20/69
- CPC G01N33/6893
- G02B6/122
- CPC G02B6/1228
- G02B26/08
- G02B6/42
- H10N30/20
- H10N30/853
- H10N30/87
- CPC G02B26/0875
- G06N3/08
- CPC G06N3/08
- G06V10/77
- A61B5/055
- G01R33/48
- G01R33/56
- G01R33/563
- G06F18/2135
- G06F18/2413
- CPC G06V10/7715
- H01M4/505
- C01G31/00
- C01G45/12
- H01M4/62
- CPC H01M4/505
- H01M10/0565
- CPC H01M10/0565
- H01S5/343
- H01S5/20
- CPC H01S5/34333
- H10N60/12
- G06N3/063
- G06N10/40
- H10N60/80
- H10N69/00
- CPC H10N60/12
