KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION (20240218358). PRIME EDITING-BASED GENE EDITING COMPOSITION WITH ENHANCED EDITING EFFICIENCY AND USE THEREOF simplified abstract
Contents
PRIME EDITING-BASED GENE EDITING COMPOSITION WITH ENHANCED EDITING EFFICIENCY AND USE THEREOF
Organization Name
KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION
Inventor(s)
Soo Ji Park of Gyeonggi-do (KR)
Tae-Yeong Jeong of Gyeonggi-do (KR)
PRIME EDITING-BASED GENE EDITING COMPOSITION WITH ENHANCED EDITING EFFICIENCY AND USE THEREOF - A simplified explanation of the abstract
This abstract first appeared for US patent application 20240218358 titled 'PRIME EDITING-BASED GENE EDITING COMPOSITION WITH ENHANCED EDITING EFFICIENCY AND USE THEREOF
The present invention is a prime editing-based gene editing composition with enhanced editing efficiency, a method for gene editing using the composition, a gene editing kit, and a method for constructing a gene-modified mammal. The prime editor developed in this invention shows significantly improved genome editing efficiency and target specificity, leading to mutation transmission and phenotype changes in the next generation of mutant animal models.
- Enhanced prime editor with improved genome editing efficiency and target specificity
- Mutant animal models exhibit mutation transmission to the next generation and phenotype changes
- Applications in constructing humanized animal models, genetic engineering, and therapeutic interventions for genetic diseases
Potential Applications:
- Construction and research of humanized animal models
- Genetic engineering in various fields
- Therapeutic interventions for genetic diseases
Problems Solved:
- Enhanced genome editing efficiency and target specificity
- Facilitates mutation transmission and phenotype changes in mutant animal models
Benefits:
- Improved gene editing capabilities
- Potential for developing new therapeutic interventions
- Advancements in genetic engineering research
Commercial Applications:
- Gene editing services for research institutions
- Development of gene therapy treatments for genetic diseases
- Production of genetically modified organisms for various industries
Questions about Gene Editing with Enhanced Efficiency: 1. How does the enhanced prime editor improve genome editing efficiency? 2. What are the potential long-term implications of using this gene editing composition?
Frequently Updated Research: Researchers are continually exploring the applications of enhanced prime editing in various genetic engineering fields, including the development of novel gene therapies and the creation of more precise genetically modified organisms.
Original Abstract Submitted
the present invention relates to a prime editing-based gene editing composition with enhanced editing efficiency, a method for gene editing by using the composition, a gene editing kit, and a method for construction of a gene-modified mammal. the prime editor developed in the present invention exhibits remarkably enhanced genome editing efficiency and target specificity and mutant animal models constructed by using same were observed to perform mutation transmission to the next generation and a phenotype change in the next generation. thus, the enhanced prime editor or a gene editing composition comprising same can find advantageous applications in various purposes, such as the construction and research of humanized animal models, the genetic engineering technical field, and therapeutic means for genetic diseases.
