INBIOSE N.V. (20240417768). PRODUCTION OF ALPHA-1,4-FUCOSYLATED COMPOUNDS

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PRODUCTION OF ALPHA-1,4-FUCOSYLATED COMPOUNDS

Organization Name

INBIOSE N.V.

Inventor(s)

Joeri Beauprez of Zwijnaarde (BE)

Kristof Vandewalle of Zwijnaarde (BE)

Annelies Vercauteren of Zwijnaarde (BE)

PRODUCTION OF ALPHA-1,4-FUCOSYLATED COMPOUNDS

This abstract first appeared for US patent application 20240417768 titled 'PRODUCTION OF ALPHA-1,4-FUCOSYLATED COMPOUNDS



Original Abstract Submitted

the present invention is in the technical field of synthetic biology, metabolic engineering and cell cultivation. the present invention describes methods for the production of a fucosylated compound comprising gal-�1,3-[fuc-�1,4]-glcnac using a fucosyltransferase as well as the purification of said fucosylated compound, said fucosyltransferase having alpha-1,4-fucosyltransferase activity on the n-acetylglucosamine (glcnac) residue of gal-�1,3-glcnac (lacto-n-biose, lnb) and/or gal-�1,3-glcnac of a saccharide substrate comprising gal-�1,3-glcnac. the present invention also provides a cell for production of a fucosylated compound comprising gal-�1,3-[fuc-�1,4]-glcnac.