INBIOSE N.V. (20240417768). PRODUCTION OF ALPHA-1,4-FUCOSYLATED COMPOUNDS
Contents
PRODUCTION OF ALPHA-1,4-FUCOSYLATED COMPOUNDS
Organization Name
Inventor(s)
Joeri Beauprez of Zwijnaarde (BE)
Kristof Vandewalle of Zwijnaarde (BE)
Annelies Vercauteren of Zwijnaarde (BE)
PRODUCTION OF ALPHA-1,4-FUCOSYLATED COMPOUNDS
This abstract first appeared for US patent application 20240417768 titled 'PRODUCTION OF ALPHA-1,4-FUCOSYLATED COMPOUNDS
Original Abstract Submitted
the present invention is in the technical field of synthetic biology, metabolic engineering and cell cultivation. the present invention describes methods for the production of a fucosylated compound comprising gal-�1,3-[fuc-�1,4]-glcnac using a fucosyltransferase as well as the purification of said fucosylated compound, said fucosyltransferase having alpha-1,4-fucosyltransferase activity on the n-acetylglucosamine (glcnac) residue of gal-�1,3-glcnac (lacto-n-biose, lnb) and/or gal-�1,3-glcnac of a saccharide substrate comprising gal-�1,3-glcnac. the present invention also provides a cell for production of a fucosylated compound comprising gal-�1,3-[fuc-�1,4]-glcnac.