INBIOSE N.V. (20240294958). EXTRACELLULAR PRODUCTION OF GLYCOSYLATED PRODUCTS simplified abstract
Contents
EXTRACELLULAR PRODUCTION OF GLYCOSYLATED PRODUCTS
Organization Name
Inventor(s)
Joeri Beauprez of Zwinjnaarde (BE)
Sofie De Maeseneire of Zwijnaarde (BE)
Yatti De Nijs of Zwijnaarde (BE)
Tom Delmulle of Zwijnaarde (BE)
EXTRACELLULAR PRODUCTION OF GLYCOSYLATED PRODUCTS - A simplified explanation of the abstract
This abstract first appeared for US patent application 20240294958 titled 'EXTRACELLULAR PRODUCTION OF GLYCOSYLATED PRODUCTS
Simplified Explanation: This patent application relates to the fermentation of metabolically engineered yeast or fungal cells to produce di- or oligosaccharides derived from UDP-GlcNAc, with a method for extracellular production and separation of the sugars from the cultivation process.
- Metabolically engineered yeast or fungal cells are used to produce di- or oligosaccharides from UDP-GlcNAc.
- The sugars are synthesized in the cytosol of the cells and then separated from the cultivation medium.
- The method allows for efficient extracellular production of these sugars, which have various potential applications.
Potential Applications: 1. Food industry for sweeteners or flavor enhancers. 2. Pharmaceutical industry for drug delivery systems. 3. Cosmetic industry for skincare products. 4. Biotechnology industry for research purposes.
Problems Solved: 1. Efficient production of di- or oligosaccharides from UDP-GlcNAc. 2. Simplified separation process from the cultivation medium. 3. Enhanced control over sugar production in yeast or fungal cells.
Benefits: 1. Increased production efficiency. 2. Diversification of sugar products. 3. Potential for novel applications in various industries.
Commercial Applications: The technology could be used in the food, pharmaceutical, cosmetic, and biotechnology industries for the production of various sugar-based products. This innovation has the potential to disrupt traditional sugar production methods and create new market opportunities.
Questions about Synthetic Biology: 1. How does the extracellular production of di- or oligosaccharides benefit industries?
- The extracellular production allows for easier extraction and purification of the sugars, making them more accessible for commercial applications.
2. What are the potential challenges in scaling up the production of metabolically engineered yeast or fungal cells for sugar production?
- Scaling up production may require optimization of fermentation conditions and genetic stability of the engineered cells to ensure consistent sugar yields.
Original Abstract Submitted
this disclosure is in the technical field of synthetic biology and metabolic engineering. more particularly, this disclosure is in the technical field of fermentation of metabolically engineered yeast or fungal cells. this disclosure describes a method for the extracellular production of a di- or oligosaccharide that is derived from udp-glcnac by a yeast or fungal cell as well as the separation of the di- or oligosaccharide from the cultivation. furthermore, this disclosure provides a metabolically engineered yeast or fungal cell for extracellular production of a di- or oligosaccharide that is derived from udp-glcnac and that is synthesized in the cytosol.
