Google llc (20240094190). Vertical Flow Assay Device and Method for Determination of Hemoglobin Concentration simplified abstract

Vertical Flow Assay Device and Method for Determination of Hemoglobin Concentration

Organization Name

google llc

Inventor(s)

Kristy Mckeating of San Francisco CA (US)

Herschel Watkins of Woodacre CA (US)

Vertical Flow Assay Device and Method for Determination of Hemoglobin Concentration - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240094190 titled 'Vertical Flow Assay Device and Method for Determination of Hemoglobin Concentration

Simplified Explanation

The present disclosure describes an assay device for measuring hemoglobin concentration in a sample, utilizing a separation membrane with a cell lysing reagent and a downstream detection membrane designed to detect hemoglobin.

• The separation membrane contains a cell lysing reagent in a specific range of 200-675 micrograms/square centimeter.
• The detection membrane is an asymmetric membrane with larger pores towards the upstream side and smaller pores towards the downstream side.
• The device uses vertical flow assay to lyse red blood cells and quantify hemoglobin levels through reflectance spectroscopy.

Potential Applications

This technology can be used in medical diagnostics, blood testing, and point-of-care devices for monitoring hemoglobin levels in patients.

Problems Solved

This device provides a quick and accurate method for determining hemoglobin concentration in blood samples without the need for complex laboratory equipment.

Benefits

The device offers a simple and efficient way to measure hemoglobin levels, making it accessible for healthcare professionals in various settings.

Potential Commercial Applications

• Medical device companies can incorporate this technology into portable hemoglobin testing devices.
• Hospitals and clinics can use this device for routine blood tests and monitoring of patients with anemia or other blood disorders.

Possible Prior Art

One possible prior art could be existing hemoglobin testing devices that use different methods for lysing red blood cells and detecting hemoglobin levels.

Unanswered Questions

How does the device handle variations in sample viscosity or composition that may affect the accuracy of hemoglobin measurement?

The abstract does not provide information on how the device compensates for potential variations in sample properties that could impact the reliability of hemoglobin concentration results.

Are there any limitations to the range of hemoglobin concentrations that can be accurately measured using this device?

The abstract does not mention any restrictions on the hemoglobin concentration levels that can be effectively quantified by the device.

Original Abstract Submitted

the present disclosure provides an assay device for determining a concentration of hemoglobin in a sample. the device includes a separation membrane containing a cell lysing reagent that is present on the separation membrane in an amount greater than 200 micrograms/square centimeter to less than 675 micrograms/square centimeter. further, the device includes a downstream detection membrane configured to elicit a quantifiable response in the presence of hemoglobin. the detection membrane includes an asymmetric membrane having a first plurality of pores located towards an upstream side of the detection membrane and a second plurality of pores located towards a downstream side of the detection membrane. the first plurality of pores are larger than the second plurality of pores. the present disclosure also provides methods for using a vertical flow assay device to lyse the red blood cells in the sample to quantify the level of hemoglobin present via reflectance spectroscopy.