DALIAN UNIVERSITY (20240344099). ENGINEERING STRAIN PRODUCING CORDYCEPIN AND ITS DERIVATIVE 3'-DEOXYINOSINE, ITS PREPARATION METHOD AND APPLICATION simplified abstract

ENGINEERING STRAIN PRODUCING CORDYCEPIN AND ITS DERIVATIVE 3'-DEOXYINOSINE, ITS PREPARATION METHOD AND APPLICATION

Organization Name

DALIAN UNIVERSITY

Inventor(s)

Qian Li of Dalian (CN)

Huiping Tan of Dalian (CN)

Baomin Feng of Dalian (CN)

Xiuping Li of Dalian (CN)

Liang Wang of Dalian (CN)

Yanghao Cheng of Dalian (CN)

Xiang Li of Dalian (CN)

Dapeng Wei of Dalian (CN)

Tuo Kan of Dalian (CN)

Chenyang Li of Dalian (CN)

Rongshuai Jiang of Dalian (CN)

ENGINEERING STRAIN PRODUCING CORDYCEPIN AND ITS DERIVATIVE 3'-DEOXYINOSINE, ITS PREPARATION METHOD AND APPLICATION - A simplified explanation of the abstract

This abstract first appeared for US patent application 20240344099 titled 'ENGINEERING STRAIN PRODUCING CORDYCEPIN AND ITS DERIVATIVE 3'-DEOXYINOSINE, ITS PREPARATION METHOD AND APPLICATION

The present invention involves genetic engineering and process engineering, specifically focusing on an engineering strain that produces cordycepin and its derivative 3′-deoxyinosine, along with its preparation method and application.

• Codon optimizing genes cm1 and cm2
• Gene amplification and fragment recovering
• Methanol-induced promoter and terminator fragments
• Inserting the genes into an expression vector and transferring for screening to obtain the engineering strain

The engineering strain can be used for the production of cordycepin and its derivative. The unique strains with cm1 and cm2 genes significantly improve the efficiency of cordycepin production, enabling a green process with carbon dioxide.

1. 1. 1. Potential Applications:

- Pharmaceutical industry for drug production - Biotechnology for research purposes - Agriculture for enhancing plant growth

1. 1. 1. Problems Solved:

- Increased efficiency in cordycepin production - Environmentally friendly production process - Enhanced genetic engineering techniques

1. 1. 1. Benefits:

- Higher yields of cordycepin and its derivative - Reduced environmental impact - Improved genetic engineering methods

1. 1. 1. Commercial Applications:
         1. Title: Enhanced Cordycepin Production Technology

This technology can be utilized in pharmaceutical companies for the production of drugs, in biotechnology research labs for experimentation, and in agriculture for improving crop yields.

1. 1. 1. Prior Art:

Readers can explore prior research on genetic engineering, process engineering, and cordycepin production techniques to understand the background of this technology.

1. 1. 1. Frequently Updated Research:

Stay updated on the latest advancements in genetic engineering, process engineering, and biotechnology to enhance the application of this technology.

1. 1. 1. 1. Questions about Cordycepin Production Technology:

1. How does the engineering strain improve cordycepin production efficiency? 2. What are the potential environmental benefits of using this technology in drug production?

Original Abstract Submitted

the present invention relates to the field of genetic engineering and process engineering, and discloses an engineering strain producing cordycepin and its derivative 3′-deoxyinosine, its preparation method and application. the method includes: codon optimizing genes cm1 and cm2; gene amplification and fragment recovering; methanol-induced promoter and terminator fragments; and inserting the genes into an expression vector and then transferring to for screening to obtain the engineering strain of of the present invention. the engineering strain can be applied to production of cordycepin and its derivative. the engineering strain prepared by the preparation method of the present invention has great advantages in producing cordycepin and its derivative. due to the use of unique strains of which have unique cm1 and cm2 genes, the efficiency of cordycepin production is greatly improved, and subsequently the green process of producing cordycepin and its derivative 3′-deoxyinosine with carbon dioxide can be realized.