BOHAI UNIVERSITY (20240239848). HOLOTHURIAN-DERIVED ACTIVE PEPTIDE WITH IMMUNE ACTIVITY, PREPARATION METHOD AND APPLICATION THEREOF simplified abstract
HOLOTHURIAN-DERIVED ACTIVE PEPTIDE WITH IMMUNE ACTIVITY, PREPARATION METHOD AND APPLICATION THEREOF
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HOLOTHURIAN-DERIVED ACTIVE PEPTIDE WITH IMMUNE ACTIVITY, PREPARATION METHOD AND APPLICATION THEREOF - A simplified explanation of the abstract
This abstract first appeared for US patent application 20240239848 titled 'HOLOTHURIAN-DERIVED ACTIVE PEPTIDE WITH IMMUNE ACTIVITY, PREPARATION METHOD AND APPLICATION THEREOF
The abstract of this patent application describes a holothurian-derived active peptide with immune activity, its preparation method, and application in biotechnology. The amino acid sequence of the active peptide is identified, and its interaction with a membrane recognition receptor is explored.
- The active peptide is derived from a holothurian and has immune activity.
- The amino acid sequence of the peptide is determined using separation and purification techniques.
- The peptide's interaction with a membrane recognition receptor is studied through molecular docking.
- The in vitro immunological activity of the peptide is confirmed through solid-phase synthesis and cell model testing.
Potential Applications: - Development of immunomodulatory therapies - Biomedical research in immune response mechanisms - Production of novel pharmaceuticals for immune-related disorders
Problems Solved: - Lack of effective immune-boosting peptides from natural sources - Limited understanding of holothurian-derived peptides and their immune activity
Benefits: - Enhanced immune response modulation - Potential for new drug development in immunology - Utilization of natural resources for biotechnological advancements
Commercial Applications: "Immunomodulatory Peptide Derived from Holothurian for Therapeutic Development in Immune Disorders"
Questions about the technology: 1. How does the peptide's interaction with Toll-like receptor 2 contribute to its immune activity? 2. What are the potential implications of using holothurian-derived peptides in pharmaceutical research and development?
Original Abstract Submitted
a holothurian-derived active peptide with immune activity, a preparation method and an application thereof are provided in the present disclosure, belonging to the field of biotechnology. the amino acid sequence of the holothurian-derived active peptide is shown in seq id no.1. the amino acid sequence of the holothurian-derived immunocompetent peptide is obtained using separation and purification techniques and mass spectrometry identification techniques with the help of the holothurian protein database, and the interaction of the immunocompetent peptide with the membrane recognition receptor (toll-like receptor 2) is explored by molecular docking technique and multiple rounds of screening, and the in vitro immunological activity of the peptide is verified by solid-phase synthesis and raw264.7 cell model.
