ACTOME GMBH (20250011464). HIGH-EFFICACY LABELING OF ANTIBODIES WITH OLIGONUCLEOTIDE LABELS
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HIGH-EFFICACY LABELING OF ANTIBODIES WITH OLIGONUCLEOTIDE LABELS
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HIGH-EFFICACY LABELING OF ANTIBODIES WITH OLIGONUCLEOTIDE LABELS
This abstract first appeared for US patent application 20250011464 titled 'HIGH-EFFICACY LABELING OF ANTIBODIES WITH OLIGONUCLEOTIDE LABELS
Original Abstract Submitted
the invention comprises a method for highly efficient selective labelling of antibodies with oligonucleotides. the method may involve the selective removal of glycans from the antibody and replacing them by artificial glycosides, especially n-glycosides including oligonucleotides. the process is believed to be facilitated by the oligonucleotide induced orientation of the antibody c′e loop and to a lesser extent by the c�2-c�3 domain. the method results in the high efficacy labelling of antibodies.
