18678358. EFFICIENT PAYLOAD EXTRACTION FROM POLYNUCLEOTIDE SEQUENCE READS simplified abstract (Microsoft Technology Licensing, LLC)

EFFICIENT PAYLOAD EXTRACTION FROM POLYNUCLEOTIDE SEQUENCE READS

Organization Name

Microsoft Technology Licensing, LLC

Inventor(s)

Konstantin Makarychev of Chicago IL (US)

EFFICIENT PAYLOAD EXTRACTION FROM POLYNUCLEOTIDE SEQUENCE READS - A simplified explanation of the abstract

This abstract first appeared for US patent application 18678358 titled 'EFFICIENT PAYLOAD EXTRACTION FROM POLYNUCLEOTIDE SEQUENCE READS

The patent application describes systems and techniques for extracting information-containing payloads from DNA or other polynucleotides. This involves decoding the sequence of payload regions from multiple polynucleotides to obtain encoded information using a polynucleotide sequencer.

• Sequencing the molecules with a polynucleotide sequencer to decode the information-containing payloads.
• Reads generated by the sequencer may include information from multiple sources mixed together.
• Primer sequences present in the reads help identify which reads contain information from the same source.
• A computationally efficient technique is used to find primer sequences in the reads by comparing hashes and computing edit distances.
• Reads with the same primer sequences may be clustered together, and sequences of the payload regions are extracted based on the locations of the primer sequences.

Potential Applications: - DNA data storage - Genetic research - Medical diagnostics

Problems Solved: - Efficient extraction of information from DNA or polynucleotides - Identification of information from different sources within the same reads

Benefits: - Improved data extraction accuracy - Faster decoding of encoded information - Enhanced research capabilities in genetics and biotechnology

Commercial Applications: "DNA Data Extraction Technology: Revolutionizing Genetic Research and Data Storage"

Questions about DNA data extraction technology: 1. How does this technology impact the field of genetic research? 2. What are the potential commercial applications of this innovation?

Original Abstract Submitted

Systems and techniques for extracting information-containing payloads from DNA or other polynucleotides are provided. Decoding the sequence of payload regions from multiple polynucleotides to obtain encoded information includes sequencing the molecules with a polynucleotide sequencer. Reads generated by the polynucleotide sequencer can include information from multiple different sources mixed together. Primer sequences present in the reads identify which reads contain information from the same source. A computationally efficient technique for finding primer sequences in the reads includes comparing hashes of the reads and hashes of primer sequences to find an approximate location then computing edit distances between the primer sequences and the reads to find an exact location. Reads that include the same primer sequences may be clustered together. Sequences of the payload regions are extracted based on the locations of the primer sequences.