18628116. METHODS FOR THE PURIFICATION OF L-GLUFOSINATE simplified abstract (BASF SE)
Contents
METHODS FOR THE PURIFICATION OF L-GLUFOSINATE
Organization Name
Inventor(s)
Stephen Craig Fields of Baltimore MD (US)
Matthew Richard Oberholzer of Wilmington DE (US)
Brian Michael Green of Lutherville MD (US)
Samir Kulkarni of East Lyme CT (US)
Jennifer Nelson of Kokomo IN (US)
Patricia Andres of West Lafayette IN (US)
METHODS FOR THE PURIFICATION OF L-GLUFOSINATE - A simplified explanation of the abstract
This abstract first appeared for US patent application 18628116 titled 'METHODS FOR THE PURIFICATION OF L-GLUFOSINATE
Abstract: Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method involves converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate to obtain substantially purified L-glufosinate. The composition is subjected to an elevated temperature to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate. The purified L-glufosinate is present in the final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate.
Key Features and Innovation:
- Isolation of L-glufosinate from a composition containing L-glufosinate and glutamate.
- Conversion of glutamate to pyroglutamate for purification of L-glufosinate.
- Use of elevated temperature for conversion and isolation process.
- Purified L-glufosinate present at a concentration of 90% or greater in the final composition.
- Potential enzymatic conversion of glutamate to pyroglutamate.
Potential Applications: The technology can be applied in the pharmaceutical industry for the production of purified L-glufosinate for various medical applications. It can also be used in agriculture for the development of herbicides.
Problems Solved: The technology addresses the challenge of isolating and purifying L-glufosinate from compositions containing glutamate, ensuring a high concentration of the desired compound in the final product.
Benefits:
- High purity of L-glufosinate in the final composition.
- Efficient conversion and isolation process.
- Versatile applications in pharmaceuticals and agriculture.
Commercial Applications: This technology has significant commercial potential in pharmaceutical manufacturing for producing high-quality L-glufosinate-based products. It can also be utilized in the agricultural sector for the development of effective herbicides.
Prior Art: Readers interested in exploring prior art related to this technology can start by researching methods for isolating and purifying amino acids from complex compositions.
Frequently Updated Research: Researchers are continually exploring new methods and techniques for enhancing the efficiency and yield of isolating L-glufosinate from compositions containing glutamate.
Questions about L-glufosinate: 1. What are the potential environmental implications of using L-glufosinate-based herbicides? 2. How does the conversion of glutamate to pyroglutamate contribute to the purification process of L-glufosinate?
Original Abstract Submitted
Compositions and methods for isolating L-glufosinate from a composition comprising L-glufosinate and glutamate are provided. The method comprises converting the glutamate to pyroglutamate followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The composition comprising L-glufosinate and glutamate is subjected to an elevated temperature for a sufficient time to allow for the conversion of glutamate to pyroglutamate, followed by the isolation of L-glufosinate from the pyroglutamate and other components of the composition to obtain substantially purified L-glufosinate. The glutamate alternatively may be converted to pyroglutamate by enzymatic conversion. The purified L-glufosinate is present in a final composition at a concentration of 90% or greater of the sum of L-glufosinate, glutamate, and pyroglutamate. In some embodiments, a portion of the glutamate in the starting composition may be separated from the L-glufosinate using a crystallization step. Solid forms of L-glufosinate materials, including crystalline L-glufosinate ammonium, are also described.
