18605260. MULTIPLEX CAPTURE OF GENE AND PROTEIN EXPRESSION FROM A BIOLOGICAL SAMPLE simplified abstract (10x Genomics, Inc.)

MULTIPLEX CAPTURE OF GENE AND PROTEIN EXPRESSION FROM A BIOLOGICAL SAMPLE

Organization Name

10x Genomics, Inc.

Inventor(s)

Jennifer Chew of Hayward CA (US)

Joseph Francis Shuga of Pleasanton CA (US)

Patrick Roelli of Stockholm (SE)

Denise Cheung of Dublin CA (US)

Alexander Hermes of Livermore CA (US)

Yifeng Yin of Elk Grove CA (US)

Naishitha Anaparthy of Dublin CA (US)

Ryo Hatori of Pleasanton CA (US)

Marlon Stoeckius of Stockholm (SE)

Rapolas Spalinskas of Pleasanton CA (US)

Anna-Maria Katsori of Stockholm (SE)

Cedric Uytingco of Milpitas CA (US)

Mesruh Turkekul of Stockholm (SE)

David Sukovich of Oakland CA (US)

Christina Galonska of Stockholm (SE)

Aleksandra Jurek of Pleasanton CA (US)

Octavian Marian Bloju of Stockholm (SE)

MULTIPLEX CAPTURE OF GENE AND PROTEIN EXPRESSION FROM A BIOLOGICAL SAMPLE - A simplified explanation of the abstract

This abstract first appeared for US patent application 18605260 titled 'MULTIPLEX CAPTURE OF GENE AND PROTEIN EXPRESSION FROM A BIOLOGICAL SAMPLE

The patent application describes methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, specifically determining the location of nucleic acid and protein analytes in a sample.

• The innovation involves techniques for analyzing gene expression and protein distribution in biological samples simultaneously.
• The methods allow for the identification of specific locations of nucleic acid and protein analytes within a sample.
• The compositions and kits provided streamline the process of preparing samples for spatial analysis, enhancing efficiency and accuracy.
• This technology enables researchers to gain a comprehensive understanding of gene expression patterns and protein localization within biological samples.
• By combining gene expression and proteomic analysis, this innovation offers a more holistic view of cellular processes and interactions.

Potential Applications: - Research in molecular biology and cellular biology - Drug discovery and development - Diagnostic applications in healthcare - Environmental monitoring and analysis - Agricultural research and biotechnology

Problems Solved: - Simplifies the process of preparing biological samples for spatial analysis - Enables simultaneous analysis of gene expression and protein distribution - Enhances the accuracy and efficiency of spatial analysis techniques

Benefits: - Comprehensive understanding of gene expression and protein localization - Improved insights into cellular processes and interactions - Streamlined sample preparation process for spatial analysis - Potential for new discoveries in various fields of research

Commercial Applications: Title: Advanced Spatial Analysis Technology for Molecular Research This technology has significant commercial potential in industries such as pharmaceuticals, biotechnology, healthcare, and environmental science. It can be utilized for drug development, biomarker discovery, disease diagnosis, and environmental monitoring, offering valuable insights for research and development efforts.

Questions about Advanced Spatial Analysis Technology for Molecular Research: 1. How does this technology improve the efficiency of spatial analysis in biological samples? 2. What are the potential implications of combining gene expression and proteomic analysis in research and development processes?

Original Abstract Submitted

Provided herein are methods, compositions, and kits for preparing biological samples for multiplex spatial gene expression and proteomic analysis, such as determining a location of a nucleic acid analyte and a protein analyte in a biological sample.