18597797. ADAM6 MICE simplified abstract (Regeneron Pharmaceuticals, Inc.)
Contents
ADAM6 MICE
Organization Name
Regeneron Pharmaceuticals, Inc.
Inventor(s)
Lynn Macdonald of Harrison NY (US)
Sean Stevens of Del Mar CA (US)
Andrew J. Murphy of Croton-on-Hudson NY (US)
Margaret Karow of Santa Rosa Valley CA (US)
ADAM6 MICE - A simplified explanation of the abstract
This abstract first appeared for US patent application 18597797 titled 'ADAM6 MICE
Simplified Explanation: The patent application describes mice with modified ADAM6 activity, allowing them to generate offspring through mating.
Key Features and Innovation:
- Mice with reduced or deleted ADAM6 activity
- Ectopic ADAM6 sequence enabling male mice to reproduce
- Genetically modified immunoglobulin heavy chain loci with ADAM6 sequences
Potential Applications: This technology could be used in genetic research, reproductive biology studies, and potentially in the development of new breeding strategies for mice.
Problems Solved: This technology addresses the need for specific genetic modifications in mice for research purposes and potentially for breeding purposes.
Benefits:
- Enhanced understanding of ADAM6 function
- Potential for new breeding strategies in mice
- Advances in genetic research using modified mouse models
Commercial Applications: Potential commercial applications could include the development of genetically modified mouse models for research institutions, pharmaceutical companies, and biotechnology firms.
Prior Art: Readers interested in prior art related to this technology could explore research on genetic modifications in mice, reproductive biology, and ADAM6 function in mammals.
Frequently Updated Research: Researchers may be conducting ongoing studies on the effects of modified ADAM6 activity in mice, as well as the implications for reproductive biology and genetic research.
Questions about ADAM6: 1. What are the potential implications of modified ADAM6 activity in male mice for breeding purposes? 2. How does the presence or absence of ADAM6 activity impact male mouse fertility?
Original Abstract Submitted
Mice are provided that comprise a reduction or deletion of ADAM6 activity from an endogenous ADAM6 locus, or that lack an endogenous locus encoding a mouse ADAM6 protein, wherein the mice comprise a sequence encoding an ADAM6 or ortholog or homolog or fragment thereof that is functional in a male mouse. In one embodiment, the sequence is an ectopic ADAM6 sequence or a sequence that confers upon a male mouse the ability to generate offspring by mating. Mice and cells with genetically modified immunoglobulin heavy chain loci that comprise an ectopic nucleotide sequence encoding a mouse ADAM6 or functional fragment or homolog or ortholog thereof are also provided.
